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Published in 2017 at "ChemMedChem"
DOI: 10.1002/cmdc.201700278
Abstract: The T‐cell‐specific retinoic acid receptor (RAR)‐related orphan receptor‐γ (RORγt) is a key transcription factor for the production of pro‐inflammatory Th17 cytokines, which are implicated in the pathogenesis of autoimmune diseases. Over the years, several structurally…
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Keywords:
natural synthetic;
synthetic compounds;
inverse agonists;
structural states ... See more keywords
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1
Published in 2019 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2019.03.004
Abstract: The ability of antibiotics to cure bacterial infections is at a serious risk due to the emergence and worldwide spread of superbugs. A lack of innovation and investment for almost 50 years has led to…
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Keywords:
synthetic compounds;
infective activity;
anti infective;
recently developed ... See more keywords
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Published in 2022 at "Current drug discovery technologies"
DOI: 10.2174/1570163819666220128145724
Abstract: • Background : The world is suffering from health and economic devastation due to the Corona Virus Disease-2019 (COVID-19) pandemic. Given the number of people affected and also the death rate, the virus is definitely…
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Keywords:
development;
sars cov;
drug;
synthetic compounds ... See more keywords
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Published in 2018 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2017.24558.6106
Abstract: Objective(s): Due to the rapid increased drug resistance to Plasmodium parasites, an urgent need to achieve new antiplasmodial drugs is felt. Therefore, in this study, the new synthetic phenanthroline derivatives were synthesized with antiplasmodial activity.…
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Keywords:
phenanthroline derivatives;
synthetic compounds;
antiplasmodial activity;
study ... See more keywords
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1
Published in 2020 at "Molecules"
DOI: 10.3390/molecules25040942
Abstract: Viral infections have resulted in millions of victims in human history. Although great efforts have been made to find effective medication, there are still no drugs that truly cure viral infections. There are currently approximately…
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Keywords:
compounds amino;
synthetic compounds;
thiadiazole moiety;
viral infections ... See more keywords
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2
Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16040616
Abstract: Exposure of many cancer cells, including multiple myeloma cells, to cytotoxic concentrations of natural products celastrol and withaferin A or synthetic compounds of the IHSF series resulted in denaturation of a luciferase reporter protein. Proteomic…
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Keywords:
disruption proteostasis;
natural products;
proteostasis natural;
multiple myeloma ... See more keywords