Scaffold-Hopping from Synthetic Drugs by Holistic Molecular Representation
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-34677-0
Abstract: The discovery of novel ligand chemotypes allows to explore uncharted regions in chemical space, thereby potentially improving synthetic accessibility, potency, and the drug-likeness of molecules. Here, we demonstrate the scaffold-hopping ability of the new Weighted… read more here.
Keywords: regions chemical; drugs holistic; scaffold hopping; chemical space ... See more keywords
Novel synthetic drugs currently in clinical development for chronic lymphocytic leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2017.1384814
Abstract: ABSTRACT Introduction: Over the last few years, several new synthetic drugs, particularly Bruton’s tyrosine kinase (BTK), phosphatidylinositol 3-kinase (PI3K) and BCL-2 inhibitors have been developed and investigated in chronic lymphocytic leukemia (CLL). Areas covered: This… read more here.
Keywords: cll; lymphocytic leukemia; clinical development; synthetic drugs ... See more keywords
HPLC/Fluorescence-Diode Array Detection for Rapid and Reliable Determination of Illegal Synthetic Drugs in Male Sexual Herbal and Honey Remedies: Comparative Study with UFLC-MS.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of AOAC International"
DOI: 10.1093/jaoacint/qsac037
Abstract: BACKGROUND Nutraceuticals, NTC, as honey and tablets with herbal extract are subjected to adulteration. OBJECTIVE For NTCs claimed to enhance sexual performance, synthetic drugs (sildenafil, tadalafil, avanafil, vardenafil and dapoxetine) are common adulterants, so they… read more here.
Keywords: rapid reliable; synthetic drugs; hplc fluorescence; detection ... See more keywords
The Efficient Activity of Glabridin and its Derivatives Against EGFR-mediated Inhibition of Breast Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666230303120942
Abstract: BACKGROUND Breast cancer (BC) is one of the most typical causes of cancer death in women worldwide. Activated epidermal growth factor receptor (EGFR) signaling has been increasingly associated with BC development and resistance to cytotoxic… read more here.
Keywords: glabridin derivatives; synthetic drugs; egfr mediated; breast cancer ... See more keywords
Antiviral potential of Medicinal plants against Influenza Viruses: A Systematic Review
Sign Up to like & getrecommendations! Published in 2023 at "Research Journal of Pharmacy and Technology"
DOI: 10.52711/0974-360x.2023.00247
Abstract: Influenza is a considerable public health hazard that affects people worldwide. Effective diagnosis and timely treatment are critical for the influenza virus. The current review primarily focuses on isolating a novel, cost-effective anti-influenza viral. Several… read more here.
Keywords: synthetic drugs; review; influenza; medicinal plants ... See more keywords