Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer.
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DOI: 10.1158/2159-8290.cd-21-0680
Abstract: Inactivation of the adenomatous polyposis coli (APC) is common across many cancer types and serves as a critical initiating event in most sporadic colorectal cancers (CRC). APC-deficiency activates WNT signaling which remains an elusive target… read more here.
Keywords: tdo2; synthetic essentiality; cancer; tryptophan dioxygenase ... See more keywords