Computational Re-design of Synthetic Genetic Oscillators for Independent Amplitude and Frequency Modulation.
Sign Up to like & getrecommendations! Published in 2018 at "Cell systems"
DOI: 10.1016/j.cels.2018.03.013
Abstract: To perform well in biotechnology applications, synthetic genetic oscillators must be engineered to allow independent modulation of amplitude and period. This need is currently unmet. Here, we demonstrate computationally how two classic genetic oscillators, the… read more here.
Keywords: computational design; modulation; genetic oscillators; design synthetic ... See more keywords
Exploring the Chemistry of Genetic Information Storage and Propagation through Polymerase Engineering
Sign Up to like & getrecommendations! Published in 2017 at "Accounts of Chemical Research"
DOI: 10.1021/acs.accounts.7b00056
Abstract: Conspectus Nucleic acids are a distinct form of sequence-defined biopolymer. What sets them apart from other biopolymers such as polypeptides or polysaccharides is their unique capacity to encode, store, and propagate genetic information (molecular heredity).… read more here.
Keywords: genetic polymers; chemistry; heredity; genetic information ... See more keywords
A novel synthetic-genetic-array based yeast one-hybrid system for high discovery rate and short processing time.
Sign Up to like & getrecommendations! Published in 2019 at "Genome research"
DOI: 10.1101/gr.245951.118
Abstract: The eukaryotic gene expression is often tightly regulated by interactions between transcription factors (TFs) and their DNA cis-targets. Yeast one-hybrid (Y1H) is one of the most extensively used methods to discover these interactions. We developed… read more here.
Keywords: hybrid system; one hybrid; system; genetic array ... See more keywords
Synthetic genetic circuits as a means of reprogramming plant roots
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DOI: 10.1126/science.abo4326
Abstract: The shape of a plant’s root system influences its ability to reach essential nutrients in the soil and to acquire water during drought. Progress in engineering plant roots to optimize water and nutrient acquisition has… read more here.
Keywords: synthetic genetic; genetic circuits; gene expression; plant ... See more keywords
Abstract PO-104: Phenotypic mapping of pathological crosstalk between glioblastoma and innate immune cells by synthetic genetic tracing
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.tumhet2020-po-104
Abstract: Glioblastoma is a lethal brain tumor with a high degree of heterogeneity and resistance to therapy. The lack of genetic tracing approaches to selectively identify tumor states and fate transitions limited our understanding of tumor… read more here.
Keywords: genetic tracing; glioblastoma; immune cells; innate immune ... See more keywords