DNA methylome signatures of prenatal exposure to synthetic glucocorticoids in hippocampus and peripheral whole blood of female guinea pigs in early life
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DOI: 10.1038/s41398-020-01186-6
Abstract: Synthetic glucocorticoids (sGC) are administered to women at risk of preterm delivery, approximately 10% of all pregnancies. In animal models, offspring exposed to elevated glucocorticoids, either by administration of sGC or endogenous glucocorticoids as a… read more here.
Keywords: methylation; dna; synthetic glucocorticoids; exposure ... See more keywords
Modeling the influence of chronopharmacological administration of synthetic glucocorticoids on the hypothalamic-pituitary-adrenal axis
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DOI: 10.1080/07420528.2018.1498098
Abstract: ABSTRACT Natural glucocorticoids, a class of cholesterol-derived hormones, modulate an array of metabolic, anti-inflammatory, immunosuppressive and cognitive signaling. The synthesis of natural glucocorticoids, largely cortisol in humans, is regulated by the hypothalamic-pituitary-adrenal (HPA) axis and… read more here.
Keywords: administration; hpa axis; axis; hypothalamic pituitary ... See more keywords
A Single Course of Synthetic Glucocorticoids in Pregnant Guinea Pigs Programs Behavior and Stress Response in Two Generations of Offspring.
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DOI: 10.1210/en.2018-00666
Abstract: Treatment with a single course of synthetic glucocorticoids (sGCs) is the standard of care for pregnant women who are at risk for preterm delivery. Animal studies have demonstrated that multiple course sGCs can program altered… read more here.
Keywords: pregnant guinea; response; synthetic glucocorticoids; course ... See more keywords