Synthetic α‐Helical Peptides as Potential Inhibitors of the ACE2 SARS‐CoV‐2 Interaction
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DOI: 10.1002/cbic.202200372
Abstract: During viral cell entry, the spike protein of SARS‐CoV‐2 binds to the α1‐helix motif of human angiotensin‐converting enzyme 2 (ACE2). Thus, alpha‐helical peptides mimicking this motif may serve as inhibitors of viral cell entry. For this… read more here.
Keywords: peptides potential; potential inhibitors; helical peptides; synthetic helical ... See more keywords
Synthetic helical peptide capping strategies.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Society reviews"
DOI: 10.1039/d1cs01175h
Abstract: Relatively small mimics of interface secondary structures can be used to disrupt protein-protein interactions (PPIs). This strategy is valuable because many PPIs are pivotal in cell biology and contemporary medicinal chemistry. Small peptides tend to… read more here.
Keywords: capping strategies; peptide; peptide capping; synthetic helical ... See more keywords