A synthetic human antibody antagonizes IL-18Rβ signaling through an allosteric mechanism.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.01.012
Abstract: The interleukin-18 subfamily belongs to the interleukin-1 family and plays important roles in modulating innate and adaptive immune responses. Dysregulation of IL-18 has been implicated in or correlated with numerous diseases including inflammatory diseases, autoimmune… read more here.
Keywords: antibody antagonizes; allosteric mechanism; synthetic human; human antibody ... See more keywords
Synthetic human proteomes for accelerating protein research
Sign Up to like & getrecommendations! Published in 2017 at "Nature Methods"
DOI: 10.1038/nmeth.4191
Abstract: The generation of synthetic human proteomes and future derived tools will expand knowledge in protein biology. read more here.
Keywords: accelerating protein; proteomes accelerating; human proteomes; protein research ... See more keywords
Artificial strain of human prions created in vitro
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04584-z
Abstract: The molecular mechanism that determines under physiological conditions transmissibility of the most common human prion disease, sporadic Creutzfeldt-Jakob disease (sCJD) is unknown. We report the synthesis of new human prion from the recombinant human prion… read more here.
Keywords: prion; prion protein; human prions; strain ... See more keywords
Technical versus biological variability in a synthetic human gut community
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2155019
Abstract: ABSTRACT Synthetic communities grown in well-controlled conditions are an important tool to decipher the mechanisms driving community dynamics. However, replicate time series of synthetic human gut communities in chemostats are rare, and it is thus… read more here.
Keywords: community; variability; gut community; synthetic human ... See more keywords
Ascorbate and Antibiotics, at Concentrations Attainable in Urine, Can Inhibit the Growth of Resistant Strains of Escherichia coli Cultured in Synthetic Human Urine
Sign Up to like & getrecommendations! Published in 2023 at "Antibiotics"
DOI: 10.3390/antibiotics12060985
Abstract: There are conflicting reports on the antibacterial activity of ascorbate; all at concentrations much higher than the typical in human plasma, but that can be reached in urine. The effect of 10 mM ascorbate (in… read more here.
Keywords: human urine; effect; escherichia coli; ascorbate ... See more keywords
Recurrent neural networks enable design of multifunctional synthetic human gut microbiome dynamics
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.73870
Abstract: Predicting the dynamics and functions of microbiomes constructed from the bottom-up is a key challenge in exploiting them to our benefit. Current models based on ecological theory fail to capture complex community behaviors due to… read more here.
Keywords: neural networks; recurrent neural; design; model ... See more keywords