Synthetic Integrin-Targeting Dextran-Fc Hybrids Efficiently Inhibit Tumor Proliferation In Vitro.
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DOI: 10.26083/tuprints-00019433
Abstract: Herein, we present the design, synthesis, and biological evaluation of novel integrin-targeting molecular hybrids combining RGD peptides and a potent cytotoxin presented on dextran polysaccharides. Based on an aglycosylated Fc as a centerpiece, endosomal-cleavable cytotoxic… read more here.
Keywords: synthetic integrin; integrin; hybrids efficiently; dextran hybrids ... See more keywords