PARP inhibitors in breast cancer: Bringing synthetic lethality to the bedside
Sign Up to like & getrecommendations! Published in 2018 at "Cancer"
DOI: 10.1002/cncr.31307
Abstract: Individuals with breast and ovarian cancer susceptibility gene 1 (BRCA1) or BRCA2 germline mutations have a significantly increased lifetime risk for breast and ovarian cancers. BRCA‐mutant cancer cells have abnormal homologous recombination (HR) repair of… read more here.
Keywords: cancer; parp inhibitors; breast cancer; synthetic lethality ... See more keywords
Targeting epigenetics using synthetic lethality in precision medicine
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-018-2866-0
Abstract: Technological breakthroughs in genomics have had a significant impact on clinical therapy for human diseases, allowing us to use patient genetic differences to guide medical care. The “synthetic lethal approach” leverages on cancer-specific genetic rewiring… read more here.
Keywords: medicine; targeting epigenetics; epigenetics using; lethality precision ... See more keywords
Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines.
Sign Up to like & getrecommendations! Published in 2021 at "Cell systems"
DOI: 10.1016/j.cels.2021.08.006
Abstract: Pairs of paralogs may share common functionality and, hence, display synthetic lethal interactions. As the majority of human genes have an identifiable paralog, exploiting synthetic lethality between paralogs may be a broadly applicable approach for… read more here.
Keywords: cell lines; synthetic lethality; cancer; paralog ... See more keywords
Exploiting Synthetic Lethality and Network Biology to Overcome EGFR Inhibitor Resistance in Lung Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.04.018
Abstract: Despite the recent approval of third-generation therapies, overcoming resistance to epidermal growth factor receptor (EGFR) inhibitors remains a major challenge in non-small cell lung cancer. Conceptually, synthetic lethality holds the promise of identifying non-intuitive targets… read more here.
Keywords: synthetic lethality; resistance; biology; lung cancer ... See more keywords
Capitalizing on Synthetic Lethality of MYC to Treat Cancer in the Digital Age.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2020.11.014
Abstract: Deregulation of MYC is among the most frequent oncogenic drivers of cancer. Developing targeted therapies against MYC is, therefore, one of the most critical unmet needs of cancer therapy. Unfortunately, MYC has been labelled as… read more here.
Keywords: synthetic lethality; capitalizing synthetic; lethality myc; cancer ... See more keywords
ERCC1-XPF deficiency is a predictor of olaparib induced synthetic lethality and platinum sensitivity in epithelial ovarian cancers.
Sign Up to like & getrecommendations! Published in 2019 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2019.02.014
Abstract: PURPOSE PARP inhibitor maintenance therapy in platinum sensitive sporadic ovarian cancers improves progression free survival. However, biomarker for synthetic lethality in platinum sensitive sporadic disease is yet to be defined. ERCC1-XPF heterodimer is a key… read more here.
Keywords: platinum sensitivity; platinum; ercc1 xpf; ovarian cancers ... See more keywords
Discovery of 4-Hydroxyquinazoline Derivatives as Small Molecular BET/PARP1 Inhibitors That Induce Defective Homologous Recombination and Lead to Synthetic Lethality for Triple-Negative Breast Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00135
Abstract: The effective potency and resistance of poly(ADP-ribose) polymerase (PARP) inhibitors limit their application. Here, we exploit a new paradigm that mimics the effects of breast cancer susceptibility genes (BRCA) mutations to trigger the possibility of… read more here.
Keywords: lethality; synthetic lethality; breast cancer; parp1 ... See more keywords
Synthetic lethality screens point the way to new cancer drug targets
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Drug Discovery"
DOI: 10.1038/nrd.2017.190
Abstract: This corrects the article DOI: 10.1038/nrd.2017.165 read more here.
Keywords: lethality screens; point way; drug; screens point ... See more keywords
Molecular disruption of DNA polymerase β for platinum sensitisation and synthetic lethality in epithelial ovarian cancers
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01710-y
Abstract: Targeting PARP1 [Poly(ADP-Ribose) Polymerase 1] for synthetic lethality is a new strategy for BRCA germ-line mutated or platinum sensitive ovarian cancers. However, not all patients respond due to intrinsic or acquired resistance to PARP1 inhibitor.… read more here.
Keywords: synthetic lethality; ovarian cancers; platinum; dna polymerase ... See more keywords
Exploiting synthetic lethality to target BRCA1/2-deficient tumors: where we stand
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DOI: 10.1038/s41388-021-01744-2
Abstract: The principle of synthetic lethality, which refers to the loss of viability resulting from the disruption of two genes, which, individually, do not cause lethality, has become an attractive target approach due to the development… read more here.
Keywords: synthetic lethality; exploiting synthetic; lethality target; target brca1 ... See more keywords
Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17958-z
Abstract: In response to DNA damage, a synthetic lethal relationship exists between the cell cycle checkpoint kinase MK2 and the tumor suppressor p53. Here, we describe the concept of augmented synthetic lethality (ASL): depletion of a… read more here.
Keywords: synthetic lethality; p53; response; cell cycle ... See more keywords