Design of TLR2-ligand-synthetic long peptide conjugates for therapeutic vaccination of chronic HBV patients.
Sign Up to like & getrecommendations! Published in 2020 at "Antiviral research"
DOI: 10.1016/j.antiviral.2020.104746
Abstract: Synthetic long peptide (SLP) vaccination is a promising new treatment strategy for patients with a chronic hepatitis B virus (HBV) infection. We have previously shown that a prototype HBV-core protein derived SLP was capable of… read more here.
Keywords: chronic hbv; synthetic long; tlr2 ligand; slp ... See more keywords
Efficient detection and assembly of non-reference DNA sequences with synthetic long reads
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac653
Abstract: Abstract Recent pan-genome studies have revealed an abundance of DNA sequences in human genomes that are not present in the reference genome. A lion’s share of these non-reference sequences (NRSs) cannot be reliably assembled or… read more here.
Keywords: dna; reference; synthetic long; non reference ... See more keywords
Efficient Eradication of Established Tumors in Mice with Cationic Liposome-Based Synthetic Long-Peptide Vaccines
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-16-0283
Abstract: Effective antitumor vaccines have been elusive. Two tumor models were used to test vaccines comprising liposome-encapsulated synthetic long peptides and TLR-activating adjuvants. These could cure 75–100% of the mice of large established HPV-expressing tumors and… read more here.
Keywords: eradication established; synthetic long; efficient eradication; liposome ... See more keywords
Vaccination with synthetic long peptide formulated with CpG in an oil-in-water emulsion induces robust E7-specific CD8 T cell responses and TC-1 tumor eradication
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-5725-y
Abstract: BackgroundDespite considerable efforts at developing therapeutic vaccines for cancer, clinical translation of preclinical successes has been challenging, largely due to the difficulty of inducing strong and sustained cytotoxic T lymphocyte (CTL) responses in patients. Several… read more here.
Keywords: synthetic long; cd8; water; vaccine format ... See more keywords