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Published in 2019 at "Tetrahedron letters"
DOI: 10.1016/j.tetlet.2018.12.033
Abstract: Benzosuberene analogues (1 and 2) and dihydronaphthalene analogues (3 and 4) function as potent inhibitors of tubulin polymerization, demonstrate pronounced cytotoxicity (low nM to pM range) against human cancer cell lines, and are promising vascular…
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Keywords:
dihydronaphthalene;
methodology;
efficient synthetic;
methodology construction ... See more keywords
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Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b03111
Abstract: Flexible synthetic access to a novel biarylic GC binding motif is presented, consisting of a pyridone connected to a fused pyrrolo[2,3- b]pyridone. Extensive molecular modeling led to an optimized design with perfect complementarity to the…
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Keywords:
pyrrolo pyridones;
methodology;
toward pyrrolo;
synthetic methodology ... See more keywords