Protein-recruiting synthetic molecules targeting the Golgi surface.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc06908f
Abstract: Organelle-localizable small-molecule ligands are valuable tools for spatiotemporally controlling protein localization and signaling processes in living cells. Here, we present synthetic ligands that specifically localize to the Golgi surface. The ligands can rapidly recruit their… read more here.
Keywords: golgi surface; synthetic molecules; surface; recruiting synthetic ... See more keywords
Melding Synthetic Molecules and Genetically Encoded Proteins to Forge New Tools for Neuroscience.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of neuroscience"
DOI: 10.1146/annurev-neuro-110520-030031
Abstract: Unraveling the complexity of the brain requires sophisticated methods to probe and perturb neurobiological processes with high spatiotemporal control. The field of chemical biology has produced general strategies to combine the molecular specificity of small-molecule… read more here.
Keywords: neuroscience; neuroscience melding; molecules genetically; synthetic molecules ... See more keywords
Assessment of Anticholinergic and Antidiabetic Properties of Some Natural and Synthetic Molecules: an In Vitro and In Silico Approach.
Sign Up to like & getrecommendations! Published in 2023 at "Current computer-aided drug design"
DOI: 10.2174/1573409919666230518151414
Abstract: INTRODUCTION In this study, it was aimed to determine the in vitro and in silico effects of some natural and synthetic molecules on acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and α-glucosidase enzymes. BACKGROUND Alzheimer's disease (AD) and… read more here.
Keywords: effect; bche; synthetic molecules; enzyme ... See more keywords