Synthetic mRNA‐Based Systems in Mammalian Cells
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Biosystems"
DOI: 10.1002/adbi.201900247
Abstract: Living organisms are programmed to perform multiple functions by sensing intra‐ and extra‐cellular environments and by controlling gene expressions. Synthetic biologists aim to program cells by mimicking, designing, and constructing genetic circuits. Synthetic mRNA‐based genetic… read more here.
Keywords: based systems; synthetic mrna; mrna based; systems mammalian ... See more keywords
Efficient reduction of synthetic mRNA induced immune activation by simultaneous delivery of B18R encoding mRNA
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biological Engineering"
DOI: 10.1186/s13036-019-0172-5
Abstract: The application of synthetic modified messenger RNA (mRNA) is a promising approach for the treatment of a variety of diseases and vaccination. In the past few years, different modifications of synthetic mRNA were applied to… read more here.
Keywords: synthetic mrna; immune activation; b18r encoding; encoding mrna ... See more keywords
RNase H-based analysis of synthetic mRNA 5′ cap incorporation
Sign Up to like & getrecommendations! Published in 2022 at "RNA"
DOI: 10.1261/rna.079173.122
Abstract: Advances in mRNA synthesis and lipid nanoparticles technologies have helped make mRNA therapeutics and vaccines a reality. The 5’ cap structure is a crucial modification required to functionalize synthetic mRNA for efficient protein translation in… read more here.
Keywords: rnase based; cap; rnase; analysis ... See more keywords
Lipofection with Synthetic mRNA as a Simple Method for T-Cell Immunomonitoring
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13071232
Abstract: The quantification of T-cell immune responses is crucial for the monitoring of natural and treatment-induced immunity, as well as for the validation of new immunotherapeutic approaches. The present study presents a simple method based on… read more here.
Keywords: synthetic mrna; lipofection synthetic; simple method; cell ... See more keywords