Illicit synthetic opioid consumption in Asia and the Pacific: Assessing the risks of a potential outbreak.
Sign Up to like & getrecommendations! Published in 2021 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2020.108500
Abstract: BACKGROUND Illegally manufactured potent synthetic opioids (IMPSO) like fentanyl have contributed to rises in overdose deaths in parts of North America and Europe. While many of these substances are produced in Asia, there is little… read more here.
Keywords: asia pacific; illicit synthetic; impso; opioid consumption ... See more keywords
Pharmacodynamics and pharmacokinetics of the novel synthetic opioid, U-47700, in male rats
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108195
Abstract: Novel synthetic opioids are appearing in recreational drug markets worldwide as adulterants in heroin or ingredients in counterfeit analgesic medications. 3,4-Dichloro-N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) is an example of a non-fentanyl synthetic opioid linked to overdose deaths. Here,… read more here.
Keywords: opioid 47700; novel synthetic; pharmacokinetics novel; pharmacodynamics pharmacokinetics ... See more keywords
Monoclonal Antibodies for Combating Synthetic Opioid Intoxication.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b04872
Abstract: Opioid abuse in the United States has been declared a national crisis and is exacerbated by an inexpensive, readily available and illicit supply of synthetic opioids. Specifically, fentanyl and related analogues such as carfentanil pose… read more here.
Keywords: monoclonal antibodies; opioid intoxication; synthetic opioids; antibodies combating ... See more keywords
Metabolic profile determination of 2F‐viminol – A novel synthetic opioid identified in forensic investigations
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Forensic Sciences"
DOI: 10.1111/1556-4029.15169
Abstract: Novel synthetic opioid (NSO) continue to emerge in the United States in the midst of an opioid crisis. The NSO 2F‐viminol was identified in casework at the Center for Forensic Science Research and Education through… read more here.
Keywords: metabolism; synthetic opioid; novel synthetic; viminol ... See more keywords
The Effect of Naloxone Access Laws on Fatal Synthetic Opioid Overdose Fatality Rates
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Primary Care & Community Health"
DOI: 10.1177/21501319221147246
Abstract: Background: Increases in fatal synthetic opioid overdoses over the past 8 years have left states scrambling for effective means to curtail these deaths. Many states have implemented policies and increased service capacity to address this rise.… read more here.
Keywords: fatal synthetic; synthetic opioid; opioid overdose; death ... See more keywords
Fentanyl analogue overdose: Key lessons in management in the synthetic opioid age.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of opioid management"
DOI: 10.5055/jom.2019.0531
Abstract: Fentanyl overdoses are growing at an alarming rate. Fentanyl is often mixed into heroin and counterfeit prescription opioid pills without the customer's knowledge and only detected upon laboratory analysis. This is problematic because fentanyl analogues… read more here.
Keywords: management; synthetic opioid; fentanyl analogue; opioid ... See more keywords
Harnessing endogenous opioids for pain relief: Fantasy vs reality.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of opioid management"
DOI: 10.5055/jom.2020.0552
Abstract: OBJECTIVE To review evidence demonstrating efficacy and feasibility of harnessing the activity of endogenous opioid analgesic systems for pain management. METHODS The authors sought to summarize a wealth of data that establish proof of concept… read more here.
Keywords: pain relief; endogenous opioid; endogenous opioids; synthetic opioid ... See more keywords