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   Articles with "synthetic opioid" as a keyword



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Illicit synthetic opioid consumption in Asia and the Pacific: Assessing the risks of a potential outbreak.

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recommendations! Published in 2021 at "Drug and alcohol dependence"

DOI: 10.1016/j.drugalcdep.2020.108500

Abstract: BACKGROUND Illegally manufactured potent synthetic opioids (IMPSO) like fentanyl have contributed to rises in overdose deaths in parts of North America and Europe. While many of these substances are produced in Asia, there is little… read more here.

Keywords: asia pacific; illicit synthetic; impso; opioid consumption ... See more keywords
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Pharmacodynamics and pharmacokinetics of the novel synthetic opioid, U-47700, in male rats

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recommendations! Published in 2020 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2020.108195

Abstract: Novel synthetic opioids are appearing in recreational drug markets worldwide as adulterants in heroin or ingredients in counterfeit analgesic medications. 3,4-Dichloro-N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) is an example of a non-fentanyl synthetic opioid linked to overdose deaths. Here,… read more here.

Keywords: opioid 47700; novel synthetic; pharmacokinetics novel; pharmacodynamics pharmacokinetics ... See more keywords

Searching for Synthetic Opioid Rescue Agents: Identification of a Potent Opioid Agonist with Reduced Respiratory Depression.

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recommendations! Published in 2024 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.4c00333

Abstract: While in the process of designing more effective synthetic opioid rescue agents, we serendipitously identified a new chemotype of potent synthetic opioid. Here, we report that conformational constraint of a piperazine ring converts a mu… read more here.

Keywords: opioid rescue; rescue agents; synthetic opioid; respiratory depression ... See more keywords

Monoclonal Antibodies for Combating Synthetic Opioid Intoxication.

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recommendations! Published in 2019 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.9b04872

Abstract: Opioid abuse in the United States has been declared a national crisis and is exacerbated by an inexpensive, readily available and illicit supply of synthetic opioids. Specifically, fentanyl and related analogues such as carfentanil pose… read more here.

Keywords: monoclonal antibodies; opioid intoxication; synthetic opioids; antibodies combating ... See more keywords

B-275 Trends of urine drug testing findings in a pediatric hospital from 2019 to 2023

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recommendations! Published in 2024 at "Clinical Chemistry"

DOI: 10.1093/clinchem/hvae106.632

Abstract: Semi-quantitative immunoassays (IA) are commonly used as the initial urine drug screen (UDS), with positive results confirmed by additional testing. However, substantial false negative (FN) rates have been reported in the classes of opioids and… read more here.

Keywords: pediatric hospital; 2019 2023; class; synthetic opioid ... See more keywords

Metabolic profile determination of 2F‐viminol – A novel synthetic opioid identified in forensic investigations

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recommendations! Published in 2022 at "Journal of Forensic Sciences"

DOI: 10.1111/1556-4029.15169

Abstract: Novel synthetic opioid (NSO) continue to emerge in the United States in the midst of an opioid crisis. The NSO 2F‐viminol was identified in casework at the Center for Forensic Science Research and Education through… read more here.

Keywords: metabolism; synthetic opioid; novel synthetic; viminol ... See more keywords

The Effect of Naloxone Access Laws on Fatal Synthetic Opioid Overdose Fatality Rates

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recommendations! Published in 2023 at "Journal of Primary Care & Community Health"

DOI: 10.1177/21501319221147246

Abstract: Background: Increases in fatal synthetic opioid overdoses over the past 8 years have left states scrambling for effective means to curtail these deaths. Many states have implemented policies and increased service capacity to address this rise.… read more here.

Keywords: fatal synthetic; synthetic opioid; opioid overdose; death ... See more keywords

The synthetic opioid fentanyl increases HIV replication in macrophages

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recommendations! Published in 2025 at "PLOS One"

DOI: 10.1371/journal.pone.0298341

Abstract: Background The illicit use of synthetic opioids such as fentanyl has led to a serious public health crisis in the US. People with opioid use disorder are more likely to contract infections such as HIV… read more here.

Keywords: fentanyl; hiv; hiv replication; synthetic opioid ... See more keywords

Fentanyl analogue overdose: Key lessons in management in the synthetic opioid age.

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recommendations! Published in 2019 at "Journal of opioid management"

DOI: 10.5055/jom.2019.0531

Abstract: Fentanyl overdoses are growing at an alarming rate. Fentanyl is often mixed into heroin and counterfeit prescription opioid pills without the customer's knowledge and only detected upon laboratory analysis. This is problematic because fentanyl analogues… read more here.

Keywords: management; synthetic opioid; fentanyl analogue; opioid ... See more keywords

Harnessing endogenous opioids for pain relief: Fantasy vs reality.

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recommendations! Published in 2019 at "Journal of opioid management"

DOI: 10.5055/jom.2020.0552

Abstract: OBJECTIVE To review evidence demonstrating efficacy and feasibility of harnessing the activity of endogenous opioid analgesic systems for pain management. METHODS The authors sought to summarize a wealth of data that establish proof of concept… read more here.

Keywords: pain relief; endogenous opioid; endogenous opioids; synthetic opioid ... See more keywords