Production of interferon-gamma, interleukin-6, and interleukin-1β by human peripheral blood mononuclear cells stimulated with novel lys-gingipain synthetic peptides.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of periodontology"
DOI: 10.1002/jper.18-0626
Abstract: BACKGROUND Periodontitis is a progressive inflammatory process, and its pathogenesis is related to the presence of a dysbiotic subgingival biofilm that elicits the immune response. Porphyromonas gingivalis is a keystone pathogen, and its Lys-gingipain (Kgp)… read more here.
Keywords: peripheral blood; lys gingipain; production; synthetic peptides ... See more keywords
Resourcing, annotating, and analysing synthetic peptides of SARS‐CoV‐2 for immunopeptidomics and other immunological studies
Sign Up to like & getrecommendations! Published in 2021 at "Proteomics"
DOI: 10.1002/pmic.202100036
Abstract: SARS‐CoV‐2 has caused a significant ongoing pandemic worldwide. A number of studies have examined the T cell mediated immune responses against SARS‐CoV‐2, identifying potential T cell epitopes derived from the SARS‐CoV‐2 proteome. Such studies will… read more here.
Keywords: synthetic peptides; annotating analysing; analysing synthetic; sars cov ... See more keywords
A molecular docking study revealed that synthetic peptides induced conformational changes in the structure of SARS-CoV-2 spike glycoprotein, disrupting the interaction with human ACE2 receptor
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Biological Macromolecules"
DOI: 10.1016/j.ijbiomac.2020.07.174
Abstract: Abstract The global outbreak of COVID-19 (Coronavirus Disease 2019) caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome caused by Coronavirus 2) began in December 2019. Its closest relative, SARS-CoV-1, has a slightly mutated Spike (S) protein,… read more here.
Keywords: synthetic peptides; ace2 receptor; spike; interaction ... See more keywords
Antigenicity of phage clones and their synthetic peptides for the serodiagnosis of canine and human visceral leishmaniasis.
Sign Up to like & getrecommendations! Published in 2017 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2017.06.020
Abstract: In the Americas, Brazil is responsible by 90% of the cases registered of visceral leishmaniasis (VL), and Leishmania infantum is the most common parasite species responsible by disease in Brazilian dogs and humans. A precise… read more here.
Keywords: phage; visceral leishmaniasis; canine human; serodiagnosis canine ... See more keywords
Future of antimicrobial peptides derived from plants in food application – A focus on synthetic peptides
Sign Up to like & getrecommendations! Published in 2021 at "Trends in Food Science and Technology"
DOI: 10.1016/j.tifs.2021.04.010
Abstract: Abstract Background Food spoilage is caused by the undesirable growth of spoilage microorganisms in food products. This spoilage can lead to the global loss and waste of food. It is estimated that 1.3 billion tons… read more here.
Keywords: application; antimicrobial peptides; food; synthetic peptides ... See more keywords
Small Synthetic Peptides Bioconjugated to Hybrid Gold Nanoparticles Destroy Potentially Deadly Bacteria at Submicromolar Concentrations.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00706
Abstract: Synthetic antibacterial peptides are advanced weapons that scientists design and produce to confront current threats of harmful and mortal pathogens, which could affect humans in everyday life. Recently, many small amino acid sequences, greatly efficient… read more here.
Keywords: gold nanoparticles; hybrid gold; small synthetic; submicromolar concentrations ... See more keywords
Evaluation of the Hydrolysis Specificity of an Aminopeptidase from Bacillus licheniformis SWJS33 Using Synthetic Peptides and Soybean Protein Isolate.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.6b04426
Abstract: The substrate specificity of aminopeptidases has often been determined against aminoacyl-p-nitroanilide; thus, its specificity toward synthetic peptides and complex substrates remained unclear. The hydrolysis specificity of an aminopeptidase from Bacillus licheniformis SWJS33 (BLAM) was evaluated… read more here.
Keywords: aminopeptidase; hydrolysis specificity; hydrolysis; synthetic peptides ... See more keywords
High-Throughput Screening Identifies Synthetic Peptides with Antibacterial Activity against Mycobacterium abscessus and Serum Stability
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02844
Abstract: The rise in antibiotic resistance in bacteria has spawned new technological approaches for identifying novel antimicrobials with narrow specificity. Current antibiotic treatment regimens and antituberculosis drugs are not effective in treating Mycobacterium abscessus. Meanwhile, antimicrobial… read more here.
Keywords: antibacterial activity; synthetic peptides; mycobacterium abscessus; activity ... See more keywords
Synthetic peptides designed to modulate adiponectin assembly improve obesity‐related metabolic disorders
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14050
Abstract: Adiponectin, an adipokine possessing profound insulin‐sensitizing and anti‐inflammatory properties, is a potent biotherapeutic agent . The trimeric adiponectin subunit assembles into hexameric and functionally important higher molecular weight (HMW) forms, controlled by the endoplasmic reticulum… read more here.
Keywords: peptides designed; obesity; designed modulate; modulate adiponectin ... See more keywords
Combined antibiofilm activity of synthetic peptides and antifungal drugs against Candida spp.
Sign Up to like & getrecommendations! Published in 2022 at "Future microbiology"
DOI: 10.2217/fmb-2022-0053
Abstract: Introduction: Candida krusei and Candida albicans are biofilm-forming drug-resistant yeasts that cause bloodstream infections that can lead to death. Materials & methods: nystatin and itraconazole were combined with two synthetic peptides, PepGAT and PepKAA, to… read more here.
Keywords: synthetic peptides; antifungal drugs; activity; combined antibiofilm ... See more keywords
Synthetic peptides for the precise transportation of proteins of interests to selectable subcellular areas
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1062769
Abstract: Proteins, as gifts from nature, provide structure, sequence, and function templates for designing biomaterials. As first reported here, one group of proteins called reflectins and derived peptides were found to present distinct intracellular distribution preferences.… read more here.
Keywords: interests selectable; precise transportation; synthetic peptides; peptides precise ... See more keywords