Synthetic Phenolic Antioxidant TS-13 Suppresses the Growth of Lewis Lung Carcinoma and Potentiates Oncolytic Effect of Doxorubicin
Sign Up to like & getrecommendations! Published in 2019 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-019-04410-6
Abstract: ROS are important intracellular messengers; their ambiguous role in malignant processes was demonstrated in many studies. The effects of a synthetic phenolic antioxidant sodium 3-(3’-tert-butyl-4’-hydroxyphenyl)propyl thiosulfonate sodium (TS-13) on the tumor growth and oncolytic properties… read more here.
Keywords: synthetic phenolic; lung carcinoma; lewis lung; doxorubicin ... See more keywords
Synthetic phenolic antioxidants: Metabolism, hazards and mechanism of action.
Sign Up to like & getrecommendations! Published in 2021 at "Food chemistry"
DOI: 10.1016/j.foodchem.2021.129488
Abstract: Synthetic phenolic antioxidants can interact with peroxides produced by food. This paper reviews correlation between BHA, BHT and TBHQ metabolism and harms they cause and provides a theoretical basis for rational use of BHA, BHT… read more here.
Keywords: synthetic phenolic; metabolism; bht; carcinogenicity ... See more keywords
Using Physical Organic Chemistry Knowledge to Predict Unusual Metabolites of Synthetic Phenolic Antioxidants by Cytochrome P450.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00021
Abstract: Biotransformation, especially by human CYP450 enzymes, plays a crucial role in regulating the toxicity of organic compounds in organisms, but is poorly understood for most emerging pollutants, as their numerous "unusual" biotransformation reactions cannot retrieve… read more here.
Keywords: organic chemistry; phenolic antioxidants; synthetic phenolic; unusual metabolites ... See more keywords
Synthetic Phenolic Antioxidants Cause Perturbation in Steroidogenesis in Vitro and in Vivo.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental science & technology"
DOI: 10.1021/acs.est.7b05057
Abstract: Synthetic phenolic antioxidants (SPAs) are closely correlated with human life due to their extensive usages, and increasing concerns have been raised on their biosafety. The previous controversial findings caused continuous debates on their potential endocrine… read more here.
Keywords: perturbation steroidogenesis; synthetic phenolic; phenolic antioxidants; antioxidants cause ... See more keywords
Synthetic Phenolic Antioxidants in Personal Care Products in Toronto, Canada: Occurrence, Human Exposure, and Discharge via Greywater.
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DOI: 10.1021/acs.est.9b04120
Abstract: Although synthetic phenolic antioxidants (SPAs) are widely used in various personal care products (PCPs), little is known about their levels, composition profiles, human exposure, or environmental emissions. In this study, the occurrence of SPAs was… read more here.
Keywords: synthetic phenolic; personal care; bht; exposure ... See more keywords
Identification of In Vitro Metabolites of Synthetic Phenolic Antioxidants BHT, BHA, and TBHQ by LC-HRMS/MS
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DOI: 10.3390/ijms21249525
Abstract: Butylated hydroxytoluene (BHT) and its analogs, butylated hydroxyanisole (BHA) and tert-butyl-hydroquinone (TBHQ), are widely used synthetic preservatives to inhibit lipid oxidation in the food, cosmetic and pharmaceutical industries. Despite their widespread use, little is known… read more here.
Keywords: synthetic phenolic; metabolites synthetic; identification vitro; tbhq ... See more keywords