A Generic Self-Assembly Process in Microcompartments and Synthetic Protein Nanotubes.
Sign Up to like & getrecommendations! Published in 2018 at "Small"
DOI: 10.1002/smll.201704020
Abstract: Bacterial microcompartments enclose a biochemical pathway and reactive intermediate within a protein envelope formed by the shell proteins. Herein, the orientation of the propanediol-utilization (Pdu) microcompartment shell protein PduA in bacterial microcompartments and in synthetic… read more here.
Keywords: protein; protein nanotubes; orientation; synthetic protein ... See more keywords
Synthetic Protein Scaffolds for Improving R-(-)-Linalool Production in Escherichia coli.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c01101
Abstract: R-(-)-Linalool is widely used in the pharmaceutical, agrochemical, and fragrance industries; however, its applications are limited owing to low yield and high cost of production. To improve the production efficiency of R-(-)-linalool in Escherichia coli,… read more here.
Keywords: production; linalool; escherichia coli; protein scaffolds ... See more keywords
Systemic Delivery of an Adjuvant CXCR4-CXCL12 Signaling Inhibitor Encapsulated in Synthetic Protein Nanoparticles for Glioma Immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.1c07492
Abstract: Glioblastoma (GBM) is an aggressive primary brain cancer, with a 5 year survival of ∼5%. Challenges that hamper GBM therapeutic efficacy include (i) tumor heterogeneity, (ii) treatment resistance, (iii) immunosuppressive tumor microenvironment (TME), and (iv)… read more here.
Keywords: synthetic protein; cxcl12; protein nanoparticles; cxcr4 ... See more keywords
Synthetic protein quality control to enhance full-length translation in bacteria
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DOI: 10.1038/s41589-021-00736-3
Abstract: Coupled transcription and translation processes in bacteria cause indiscriminate translation of intact and truncated messenger RNAs, inevitably generating nonfunctional polypeptides. Here, we devised a synthetic protein quality control (ProQC) system that enables translation only when… read more here.
Keywords: protein quality; synthetic protein; translation; full length ... See more keywords
A synthetic protein as efficient multitarget regulator against complement over-activation
Sign Up to like & getrecommendations! Published in 2022 at "Communications Biology"
DOI: 10.1038/s42003-022-03094-5
Abstract: The complement system constitutes the innate defense against pathogens. Its dysregulation leads to diseases and is a critical determinant in many viral infections, e.g., COVID-19. Factor H (FH) is the main regulator of the alternative… read more here.
Keywords: synthetic protein; regulator; complement activation; protein ... See more keywords
Systematic studies into uniform synthetic protein nanoparticles
Sign Up to like & getrecommendations! Published in 2022 at "Beilstein Journal of Nanotechnology"
DOI: 10.3762/bjnano.13.22
Abstract: Nanoparticles are frequently pursued as drug delivery carriers due to their potential to alter the pharmacological profiles of drugs, but their broader utility in nanomedicine hinges upon exquisite control of critical nanoparticle properties, such as… read more here.
Keywords: ehd jetting; synthetic protein; blended spnps; protein nanoparticles ... See more keywords