Building on endogenous lipid mediators to design synthetic receptor ligands.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114154
Abstract: Large numbers of diverse biologically active molecules are produced from phospholipids, the constituents of biological membranes. Indeed, many lipid-derived ligands, which can undergo inter-transformation between one and another by certain kinases or enzymes, bind to… read more here.
Keywords: synthetic receptor; building endogenous; lipid mediators; design synthetic ... See more keywords
Semisynthesis of Aminomethyl-Insulin: An Atom-Economic Strategy to Increase the Affinity and Selectivity of a Protein for Recognition by a Synthetic Receptor.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00501
Abstract: Advancements in the molecular recognition of insulin by nonantibody-based means would facilitate the development of methodology for the continuous detection of insulin for the management of diabetes mellitus. Herein, we report a novel insulin derivative… read more here.
Keywords: affinity; aminomethyl insulin; synthetic receptor; insulin ... See more keywords
Elucidation and refinement of synthetic receptor mechanisms
Sign Up to like & getrecommendations! Published in 2020 at "Synthetic Biology"
DOI: 10.1093/synbio/ysaa017
Abstract: Abstract Synthetic receptors are powerful tools for engineering mammalian cell-based devices. These biosensors enable cell-based therapies to perform complex tasks such as regulating therapeutic gene expression in response to sensing physiological cues. Although multiple synthetic… read more here.
Keywords: design choices; synthetic receptor; performance; receptor ... See more keywords
Synthetic Receptor-Based Targeting Strategies to Improve Tumor Drug Delivery.
Sign Up to like & getrecommendations! Published in 2021 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-021-01919-w
Abstract: Heterogeneity in tumor expression as well as expression in normal tissues of various targets limit the usefulness of current ligand-based active targeting approaches. Incorporation of synthetic receptors, which can be recognized by delivery systems engineered… read more here.
Keywords: receptor based; delivery; improve tumor; synthetic receptor ... See more keywords