Natural or Synthetic RNA Delivery: A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles
Sign Up to like & getrecommendations! Published in 2021 at "Nano Letters"
DOI: 10.1021/acs.nanolett.1c00094
Abstract: RNA therapeutics have high potential that is yet to be fully realized, largely due to challenges involved in the appropriate delivery to target cells. Extracellular vesicles (EVs) are lipid bound nanoparticles released by cells of… read more here.
Keywords: extracellular vesicles; natural synthetic; synthetic rna; rna delivery ... See more keywords
Abstract A036: Synthetic RNA-guided combinatorial targeting of glioblastoma adaptive resistance: Dual suppression of PI3K-AKT and mesenchymal transition escape pathways
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-25-a036
Abstract: Glioblastoma remains one of the most treatment-refractory solid tumors due to rapid adaptive resistance across multiple convergent molecular pathways. In particular, persistent activation of the PI3K-AKT axis combined with mesenchymal transition (EMT) reprogramming contributes to… read more here.
Keywords: resistance; pi3k akt; synthetic rna;
A Framework for Comparison and Assessment of Synthetic RNA-Seq Data
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DOI: 10.3390/genes13122362
Abstract: The ever-growing number of methods for the generation of synthetic bulk and single cell RNA-seq data have multiple and diverse applications. They are often aimed at benchmarking bioinformatics algorithms for purposes such as sample classification,… read more here.
Keywords: synthetic rna; seq data; rna seq; framework ... See more keywords
Lysozyme Amyloid for Synthetic RNA Delivery
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DOI: 10.3390/pharmaceutics17091094
Abstract: Background/Objectives: Lysozyme-based amyloid aggregates offer a promising platform for RNA delivery due to their stability, cationic nature, biocompatibility, and ability to form well-defined structures. In this study, we evaluated their potential as drug carriers, focusing… read more here.
Keywords: lysozyme amyloid; rna delivery; delivery; rna ... See more keywords