A synthetic small molecule Isoxazole-9 protects against methamphetamine relapse
Sign Up to like & getrecommendations! Published in 2018 at "Molecular psychiatry"
DOI: 10.1038/mp.2017.46
Abstract: Adult neurogenesis in the dentate gyrus (DG) is strongly influenced by drug-taking behavior and may have a role in the etiology of drug-seeking behavior. However, mechanistic studies on the relationship of neurogenesis on drug seeking… read more here.
Keywords: neurogenesis; small molecule; drug; drug taking ... See more keywords
Engineered resistance to Zika virus in transgenic Aedes aegypti expressing a polycistronic cluster of synthetic small RNAs
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1810771116
Abstract: Significance Here, we describe the generation of Aedes aegypti mosquitoes that are engineered to be resistant to Zika virus (ZIKV) transmission. Our results demonstrate that engineered mosquitoes express a polycistronic cluster of synthetic small RNAs… read more here.
Keywords: polycistronic cluster; aedes aegypti; zikv; small rnas ... See more keywords
DIGGER-Bac: prediction of seed regions for high-fidelity construction of synthetic small RNAs in bacteria
Sign Up to like & getrecommendations! Published in 2023 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btad285
Abstract: Summary Synthetic small RNAs (sRNAs) are gaining increasing attention in the field of synthetic biology and bioengineering for efficient post-transcriptional regulation of gene expression. However, the optimal design of synthetic sRNAs is challenging because alterations… read more here.
Keywords: high fidelity; synthetic small; digger bac; seed regions ... See more keywords
Direct and tunable modulation of protein levels in rice and wheat with a synthetic small molecule
Sign Up to like & getrecommendations! Published in 2018 at "Plant Biotechnology Journal"
DOI: 10.1111/pbi.12787
Abstract: Summary Direct control of protein level enables rapid and efficient analyses of gene functions in crops. Previously, we developed the RDDK‐Shield1 (Shld1) system in the model plant Arabidopsis thaliana for direct modulation of protein stabilization… read more here.
Keywords: small molecule; synthetic small; protein levels; modulation protein ... See more keywords
Current Medicinal Insights on Synthetic Small Molecules and Natural Origin Products as PD-1/PD-L1 Inhibitors.
Sign Up to like & getrecommendations! Published in 2023 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026623666230417111616
Abstract: Cancer is one of the leading causes of death worldwide. Each year, millions of people are diagnosed with cancer; hence, researchers have always been curious and busy developing cancer treatments. Despite thousands of studies, cancer… read more here.
Keywords: synthetic small; current medicinal; small molecules; insights synthetic ... See more keywords
Synthetic Small Molecule Modulators of Hsp70 and Hsp40 Chaperones as Promising Anticancer Agents
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24044083
Abstract: A class of chaperones dubbed heat shock protein 70 (Hsp70) possesses high relevance in cancer diseases due to its cooperative activity with the well-established anticancer target Hsp90. However, Hsp70 is closely connected with a smaller… read more here.
Keywords: small molecule; molecule modulators; synthetic small; hsp70 hsp40 ... See more keywords
The targeted inhibition of Hsp90 by a synthetic small molecule, DPide offers an effective treatment strategy against TNBCs.
Sign Up to like & getrecommendations! Published in 2018 at "Oncology reports"
DOI: 10.3892/or.2018.6250
Abstract: Triple-negative breast cancers (TNBCs) are the most aggressive and metastatic subtype of breast cancers and exhibit poor clinical outcome due to the lack of drug target receptors such as estrogen receptors (ER), progesterone receptors (PR),… read more here.
Keywords: mda 231; small molecule; treatment; molecule dpide ... See more keywords