LAUSR

Synthetic studies toward melotenine A

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0 Published in 2019 at "Tetrahedron"

DOI: 10.1016/j.tet.2018.12.025

Abstract: Abstract Attempts to the construction of B/C ring and E ring in melotenine A are described. Based on para-dienone chemistry, a tactical application of tandem aminolysis/aza-Michael addition reaction was made to access highly functionalized building… read more here.

Keywords: synthetic studies; unit; toward melotenine; chemistry ... See more keywords

Synthetic studies toward bicyclic endoperoxides presenting polar side chains

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1 Published in 2018 at "Tetrahedron Letters"

DOI: 10.1016/j.tetlet.2018.10.059

Abstract: Abstract We developed a synthetic strategy for the preparation of tetrahydrofuro[2,3-c][1,2]dioxane and 2,3,8-trioxa[3,3,1]nonanes bearing polar functional groups at C3 and C4, respectively. The synthetic strategy has been applied to the synthesis of 2,3,8-trioxa[3,3,1]nonanes bearing various… read more here.

Keywords: studies toward; endoperoxides presenting; toward bicyclic; presenting polar ... See more keywords

Synthetic Studies toward DNA-Encoded Heterocycles Based on the On-DNA Formation of α,β-Unsaturated Ketones.

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1 Published in 2021 at "Organic letters"

DOI: 10.1021/acs.orglett.0c04118

Abstract: Taking advantage of the diversity-oriented synthesis strategy with α,β-unsaturated carbonyl compounds, we have successfully established the DNA-compatible transformations for various heterocyclic scaffolds. The ring-closure reactions for pyrrole, pyrrolidine, pyrazole, pyrazoline, isoxazoline, pyridine, piperidine, cyclohexenone, and… read more here.

Keywords: studies toward; toward dna; encoded heterocycles; dna ... See more keywords

Synthetic studies toward longeracemine: a SmI2-mediated spirocyclization and rearrangement cascade to construct the 2-azabicyclo[2.2.1]heptane framework†

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0 Published in 2020 at "Chemical Science"

DOI: 10.1039/d0sc03422c

Abstract: Longeracemine, a member of the Daphniphyllum family of alkaloids contains a novel carbon framework featuring a highly functionalized 2-azabicyclo[2.2.1]heptane core as part of an overall 5/6/5/5/6/5 skeleton. A synthetic intermediate containing the core of longeracemine… read more here.

Keywords: framework; synthetic studies; azabicyclo heptane; smi2 mediated ... See more keywords

Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and in vivo efficacy

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1 Published in 2022 at "Chemical Science"

DOI: 10.1039/d2sc00143h

Abstract: Brevicidine and laterocidine are two recently discovered lipopeptide antibiotics with promising antibacterial activity. Possessing a macrocyclic core, multiple positive charges, and a lipidated N-terminus, these lipopeptides exhibit potent and selective activity against Gram-negative pathogens, including… read more here.

Keywords: studies brevicidine; lipopeptide antibiotics; antibiotics including; synthetic studies ... See more keywords

Synthetic Studies toward the Myrioneuron Alkaloids

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1 Published in 2023 at "Synthesis"

DOI: 10.1055/a-2085-5934

Abstract: The Myrioneuron alkaloids are a relatively small family of plant-derived alkaloids that present an intriguing array of structural intricacy and biological properties. As such, these natural products have drawn interest from the synthetic community, resulting… read more here.

Keywords: myrioneuron alkaloids; toward myrioneuron; studies toward; synthetic studies ... See more keywords

Synthetic Studies Toward the C1-C12 Fragment of Amphidinolide U

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2 Published in 2023 at "Synlett"

DOI: 10.1055/a-2099-6389

Abstract: Amphidinolide U is a cytotoxic marine macrolide isolated from Amphidinium sp., sharing 75% of amphidinolide C backbone. We report here a synthetic study of the C1-C12 fragment of amphidinolide U. The C6-C12 pattern was built… read more here.

Keywords: c12 fragment; cross coupling; fragment amphidinolide; toward c12 ... See more keywords

Synthetic Studies on Bilobalide

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0 Published in 2020 at "Synlett"

DOI: 10.1055/s-0039-1691559

Abstract: We disclose our synthetic studies on bilobalide, which features a Diels–Alder reaction of a cyclic anhydride to form two contiguous quaternary carbon centers, desymmetrization of a symmetric diol, and construction of a cyclic acetal under… read more here.

Keywords: synthetic studies; studies bilobalide;

Synthetic Studies toward (−)-Cleistenolide: Highly Stereoselective Synthesis of New γ-Lactone Subunits

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0 Published in 2021 at "Journal of the Brazilian Chemical Society"

DOI: 10.21577/0103-5053.20200227

Abstract: This study describes the stereoselective synthesis of two new γ-lactones in 6 and 3 steps and 19 and 32% yield, respectively, directed toward the total synthesis of the natural product (−)-cleistenolide. The starting material was… read more here.

Keywords: studies toward; cleistenolide; lactone; stereoselective synthesis ... See more keywords