Natural and Synthetic Suppressor Mutations Defy Stability–Activity Tradeoffs
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DOI: 10.1021/acs.biochem.1c00805
Abstract: Thermodynamic stability represents one important constraint on protein evolution, but the molecular basis for how mutations that change stability impact fitness remains unclear. Here, we demonstrate that a prevalent global suppressor mutation in TEM β-lactamase,… read more here.
Keywords: suppressor; natural synthetic; stability; stability activity ... See more keywords