Height, but not binding epitope, affects the potency of synthetic TCR agonists.
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DOI: 10.1016/j.bpj.2021.08.027
Abstract: Under physiological conditions, peptide-MHC (pMHC) molecules can trigger T-cell receptors (TCRs) as monovalent ligands that are sparsely distributed on the plasma membrane of an antigen-presenting cell. TCRs can also be triggered by artificial clustering, such… read more here.
Keywords: tcr agonists; synthetic tcr; binding epitope; fab dna ... See more keywords