A Fully Synthetic Transcriptional Platform for a Multicellular Eukaryote.
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DOI: 10.1016/j.celrep.2016.12.025
Abstract: Regions of genomic DNA called enhancers encode binding sites for transcription factor proteins. Binding of activators and repressors increase and reduce transcription, respectively, but it is not understood how combinations of activators and repressors generate… read more here.
Keywords: synthetic transcriptional; transcription; transcriptional platform; fully synthetic ... See more keywords
Synthetic transcriptional synergy
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DOI: 10.1126/science.aax4556
Abstract: Synthetic transcription factors can mimic their naturally cooperative counterparts The architecture of transcription factors (TFs) is surprisingly modular (1). Each factor broadly consists of a DNA binding domain and an activation domain that recruits the… read more here.
Keywords: synthetic transcriptional; transcriptional synergy; biology; transcription ... See more keywords