Abstract 1599: Targeting tumor synthetic vulnerabilities and immune evasion mechanisms with CO-1002
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1599
Abstract: Cancer immunotherapy with immune checkpoint inhibitors (ICI) has shown durable clinical benefits in patients with immune-hot tumors. However, the majority of cancers are characterized by an immune-cold tumor microenvironment, which are refractory to ICI therapy.… read more here.
Keywords: tumor synthetic; targeting tumor; evasion; synthetic vulnerabilities ... See more keywords
Synthetic Vulnerabilities in the KRAS Pathway
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DOI: 10.3390/cancers14122837
Abstract: Simple Summary Despite recent dramatic progress, developing drugs that target oncogenic KRAS or its key effectors remains a major challenge for cancer research. Improving our understanding of the underlying biology of KRAS in cancer will… read more here.
Keywords: vulnerabilities kras; synthetic lethal; kras mutant; kras pathway ... See more keywords