ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma.
Sign Up to like & getrecommendations! Published in 2017 at "Cell metabolism"
DOI: 10.1016/j.cmet.2017.09.001
Abstract: Tumors undergo nutrient stress and need to reprogram their metabolism to survive. The stroma may play a critical role in this process by providing nutrients to support the epithelial compartment of the tumor. Here we… read more here.
Keywords: vulnerability p62; synthetic vulnerability; stroma; p62 deficient ... See more keywords
Targeting the Synthetic Vulnerability of PTEN-Deficient Glioblastoma Cells with MCL1 Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-20-0099
Abstract: PTEN deletion or mutation occurs in 30% to 60% of patients with glioblastoma (GBM) and is associated with poor prognosis. Efficacious therapy for this subgroup of patients is currently lacking. To identify potential target(s) to… read more here.
Keywords: gbm cells; synthetic vulnerability; pten deficient; targeting synthetic ... See more keywords