High‐density lipoprotein‐like particle formation of Synuclein variants
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12543
Abstract: α‐Synuclein (α‐Syn) is an intrinsically disordered protein in solution whose fibrillar aggregates are the hallmark of Parkinson's disease (PD). Although the specific function of α‐Syn is still unclear, its high structural plasticity is key for… read more here.
Keywords: synuclein; high density; syn; density lipoprotein ... See more keywords
Is multiple system atrophy an infectious disease?
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Neurology"
DOI: 10.1002/ana.25132
Abstract: Multiple system atrophy (MSA) is a fatal neurodegenerative disorder that causes autonomic failure, parkinsonism, and cerebellar ataxia in any combination. Pathological hallmarks of this condition are a-synucleinrich glial cytoplasmatic inclusions (GCIs). Misfolded a-synuclein aggregates can… read more here.
Keywords: system; synuclein; prion; disease ... See more keywords
Commentary on Oeckl et al., “Serum Beta‐Synuclein Is Higher in Down Syndrome and Precedes Rise of pTau181”
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26414
Abstract: Commentary on Oeckl et al., “Serum Beta-Synuclein Is Higher in Down Syndrome and Precedes Rise of pTau181” People with Down syndrome (DS) develop Alzheimer disease (AD) neuropathology by the time they are 40 years of… read more here.
Keywords: commentary oeckl; serum; synuclein; age ... See more keywords
Glial α‐synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivo
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DOI: 10.1002/glia.23671
Abstract: α‐Synucleinopathies are neurodegenerative diseases that are characterized pathologically by α‐synuclein inclusions in neurons and glia. The pathologic contribution of glial α‐synuclein in these diseases is not well understood. Glial α‐synuclein may be of particular importance… read more here.
Keywords: synuclein; vivo; expression synuclein; glial synuclein ... See more keywords
A user's guide for α‐synuclein biomarker studies in biological fluids: Perianalytical considerations
Sign Up to like & getrecommendations! Published in 2017 at "Movement Disorders"
DOI: 10.1002/mds.27090
Abstract: Parkinson's disease biomarkers are needed to increase diagnostic accuracy, to objectively monitor disease progression and to assess therapeutic efficacy as well as target engagement when evaluating novel drug and therapeutic strategies. This article summarizes perianalytical… read more here.
Keywords: synuclein; perianalytical considerations; biomarker studies; biomarker ... See more keywords
Diagnostic utility of cerebrospinal fluid α‐synuclein in Parkinson's disease: A systematic review and meta‐analysis
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DOI: 10.1002/mds.27110
Abstract: The accumulation of misfolded α‐synuclein aggregates is associated with PD. However, the diagnostic value of the α‐synuclein levels in CSF is still under investigation. read more here.
Keywords: synuclein; synuclein parkinson; utility cerebrospinal; diagnostic utility ... See more keywords
Phenotypic Heterogeneity in α‐Synucleinopathies: Straining the Difference
Sign Up to like & getrecommendations! Published in 2020 at "Movement Disorders"
DOI: 10.1002/mds.28013
Abstract: α-Synucleinopathies are a heterogeneous group of progressive neurodegenerative disorders characterized by the presence of α-synuclein aggregates and include Parkinson’s disease (PD), dementia with Lewy bodies, and multiple system atrophy (MSA). In disease, α-synuclein is believed… read more here.
Keywords: synuclein; disease; pathology; synuclein strains ... See more keywords
Alpha and Beta Synucleins: From Pathophysiology to Clinical Application as Biomarkers
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DOI: 10.1002/mds.28941
Abstract: The synuclein family includes three neuronal proteins, named α‐synuclein, β‐synuclein, and γ‐synuclein, that have peculiar structural features. α‐synuclein is largely known for being a key protein in the pathophysiology of Parkinson's disease (PD) and other… read more here.
Keywords: application; alpha beta; beta synucleins; synuclein ... See more keywords
Neuron‐Derived Misfolded α‐Synuclein in Blood: A Potential Biomarker for Parkinson's Disease?
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DOI: 10.1002/mds.29331
Abstract: To date, the clinical diagnosis of Parkinson’s disease (PD) is based on the assessment of motor and nonmotor symptoms, risk factors, and the response to levodopa. However, many patients with PD suffer from a late… read more here.
Keywords: disease; neuron derived; synuclein; parkinson disease ... See more keywords
Interactions between the Intrinsically Disordered Proteins β‐Synuclein and α‐Synuclein
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DOI: 10.1002/pmic.201800109
Abstract: Several intrinsically disordered proteins have been implicated in the process of amyloid fibril formation in neurodegenerative disease, and developing approaches to inhibit the aggregation of these intrinsically disordered proteins is critical for establishing effective therapies… read more here.
Keywords: beta synuclein; synuclein; alpha synuclein; disordered proteins ... See more keywords
Predictive Modeling of Neurotoxic α-Synuclein Polymorphs.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1546-1_17
Abstract: Assembly of monomeric α-synuclein (αS) into aggregation-resistant helically folded tetramers and related multimers is a key target for Parkinson's disease (PD). Protein dynamics hampers experimental characterization of the polymorphism of these structures and so computational… read more here.
Keywords: synuclein; modeling neurotoxic; synuclein polymorphs; neurotoxic synuclein ... See more keywords