Phenotypic Heterogeneity in α‐Synucleinopathies: Straining the Difference
Sign Up to like & getrecommendations! Published in 2020 at "Movement Disorders"
DOI: 10.1002/mds.28013
Abstract: α-Synucleinopathies are a heterogeneous group of progressive neurodegenerative disorders characterized by the presence of α-synuclein aggregates and include Parkinson’s disease (PD), dementia with Lewy bodies, and multiple system atrophy (MSA). In disease, α-synuclein is believed… read more here.
Keywords: synuclein; disease; pathology; synuclein strains ... See more keywords
CMT-3 targets different α-synuclein aggregates mitigating their toxic and inflammogenic effects
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-76927-0
Abstract: Parkinson's disease (PD) is a neurodegenerative disorder for which only symptomatic treatments are available. Repurposing drugs that target α-synuclein aggregation, considered one of the main drivers of PD progression, could accelerate the development of disease-modifying… read more here.
Keywords: synuclein; different synuclein; cmt targets; aggregates mitigating ... See more keywords
FYCO1 mediates clearance of α‐synuclein aggregates through a Rab7‐dependent mechanism
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14461
Abstract: Parkinson's disease can be caused by mutations in the α‐synuclein gene and is characterized by aggregates of α‐synuclein protein. We have previously shown that over‐expression of the small GTPase Rab7 can induce clearance of α‐synuclein… read more here.
Keywords: synuclein; synuclein aggregates; fyco1; clearance ... See more keywords
Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-019-0865-5
Abstract: Here we describe the use of an organotypic hippocampal slice model for studying α-synuclein aggregation and inter-neuronal spreading initiated by microinjection of pre-formed α-synuclein fibrils (PFFs). PFF injection at dentate gyrus (DG) templates the formation… read more here.
Keywords: synuclein; model; neuronal spreading; inter neuronal ... See more keywords
The Appendix in Parkinson’s Disease: From Vestigial Remnant to Vital Organ?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Parkinson's Disease"
DOI: 10.3233/jpd-191703
Abstract: Parkinson’s disease (PD) has long been considered a brain disease, but studies now point to the gastrointestinal (GI) tract as a potential starting point for PD. In particular, the human vermiform appendix has been implicated… read more here.
Keywords: appendix; pathology; synuclein aggregates; parkinson disease ... See more keywords
Brain Inflammation and Intracellular α-Synuclein Aggregates in Macaques after SARS-CoV-2 Infection
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14040776
Abstract: SARS-CoV-2 causes acute respiratory disease, but many patients also experience neurological complications. Neuropathological changes with pronounced neuroinflammation have been described in individuals after lethal COVID-19, as well as in the CSF of hospitalized patients with… read more here.
Keywords: intracellular synuclein; synuclein aggregates; cov infection; sars cov ... See more keywords