Distribution of α-Synuclein Aggregation in the Peripheral Tissues.
Sign Up to like & getrecommendations! Published in 2022 at "Neurochemical research"
DOI: 10.1007/s11064-022-03586-0
Abstract: Parkinson's disease (PD) is a chronic neurodegenerative disease mainly characterized by movement disorders and other non-motor symptoms, including the loss of dopaminergic neurons in the substantia nigra parts. Abnormal α-synuclein aggregation in the brain is… read more here.
Keywords: distribution synuclein; distribution; peripheral tissues; synuclein aggregation ... See more keywords
Inhibition of alpha-synuclein aggregation by AM17, a synthetic resveratrol derivative.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.08.049
Abstract: Parkinson's disease (PD) is linked to the aberrant self-assembly of the amyloid protein, α-synuclein (αS), where αS monomers aggregate to form oligomers and fibrils. Out of the three conformers, αS oligomers are the major toxic… read more here.
Keywords: synuclein aggregation; aggregation; resveratrol; inhibition alpha ... See more keywords
A SUMO1-derived peptide targeting SUMO-interacting motif inhibits α-synuclein aggregation.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.12.010
Abstract: The accumulation of α-synuclein amyloid fibrils in the brain is linked to Parkinson's disease and other synucleinopathies. The intermediate species in the early aggregation phase of α-synuclein are involved in the emergence of amyloid toxicity… read more here.
Keywords: synuclein aggregation; aggregation; sumo1; sumo1 derived ... See more keywords
LncRNA SNHG1 promotes &agr;‐synuclein aggregation and toxicity by targeting miR‐15b‐5p to activate SIAH1 in human neuroblastoma SH‐SY5Y cells
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2017.12.001
Abstract: HighlightsSNHG1 is upregulated and miR‐15b‐5p is downregulated in PD.SIAH1 promotes &agr;‐synuclein aggregation and toxicity.SIAH1 is a target gene of miR‐15b‐5p.SNHG1 is able to directly bind to miR‐15‐5p and represses miR‐15‐5p expression.SNHG1 promotes &agr;‐synuclein aggregation and… read more here.
Keywords: synuclein aggregation; snhg1; mir 15b; siah1 ... See more keywords
Identification of a New α-Synuclein Aggregation Inhibitor via Mass Spectrometry-based Screening.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00092
Abstract: The aggregation of disordered α-synuclein protein is pathogenically connected with Parkinson's disease. Therefore, discovering molecules that can inhibit the misfolding and aggregation of α-synuclein is an active research area in PD drug development. A key… read more here.
Keywords: synuclein aggregation; aggregation; mass spectrometry;
α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30808-9
Abstract: Aggregation of α-synuclein, the hallmark of α-synucleinopathies such as Parkinson’s disease, occurs in various glycosphingolipidoses. Although α-synuclein aggregation correlates with deficiencies in the lysosomal degradation of glycosphingolipids (GSL), the mechanism(s) involved in this aggregation remains… read more here.
Keywords: synuclein aggregation; aggregation; synuclein interacts; interacts directly ... See more keywords
Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45741
Abstract: Clinical studies report significant increases in acrolein (an α,β-unsaturated aldehyde) in the substantia nigra (SN) of patients with Parkinson’s disease (PD). In the present study, acrolein-induced neurotoxicity in the nigrostriatal dopaminergic system was investigated by… read more here.
Keywords: nigrostriatal dopaminergic; acrolein induced; synuclein aggregation; dopaminergic system ... See more keywords
A luminescence-based assay for monitoring changes in alpha-synuclein aggregation in living cells†
Sign Up to like & getrecommendations! Published in 2020 at "RSC advances"
DOI: 10.1039/d0ra02720k
Abstract: Parkinson’s disease is characterized by the accumulation of protein aggregates in the brain, termed Lewy bodies. Lewy bodies are predominantly composed of α-synuclein and mutations that increase the aggregation potential of α-synuclein have been associated… read more here.
Keywords: synuclein aggregation; aggregation; synuclein solubility; living cells ... See more keywords
Computational investigation on the effects of H50Q and G51D mutations on the α-Synuclein aggregation propensity
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2017.1347060
Abstract: The aggregation of α-synuclein is linked directly to the histopathology of Parkinson’s disease (PD). However, several missense mutations present in the α-synuclein gene (SNCA) have been known to be associated with PD. Several studies have… read more here.
Keywords: synuclein aggregation; aggregation; mutations synuclein; h50q g51d ... See more keywords
Inhibition of α-Synuclein Aggregation and Mature Fibril Disassembling With a Minimalistic Compound, ZPDm
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.588947
Abstract: Synucleinopathies are a group of disorders characterized by the accumulation of α-Synuclein amyloid inclusions in the brain. Preventing α-Synuclein aggregation is challenging because of the disordered nature of the protein and the stochastic nature of… read more here.
Keywords: synuclein aggregation; aggregation mature; aggregation; inhibition synuclein ... See more keywords
Neuronal Oxidative Stress Promotes α-Synuclein Aggregation In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11122466
Abstract: Both genetic and environmental factors increase risk for Parkinson’s disease. Many of the known genetic factors influence α-synuclein aggregation or degradation, whereas most of the identified environmental factors produce oxidative stress. Studies using in vitro… read more here.
Keywords: stress; synuclein aggregation; oxidative stress; neuronal oxidative ... See more keywords