Discerning Modulation of α-Synuclein Amyloid Assembly by α-Crystallin.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.3c00052
Abstract: Altered protein folding leading to the formation of structured aggregates such as amyloid fibrils has gained significant attention due to its association with neurodegenerative diseases. α-Synuclein, a small intrinsically disordered protein, gets transformed into amyloid… read more here.
Keywords: crystallin; modulation synuclein; chaperone like; synuclein amyloid ... See more keywords
Correlation between cellular uptake and cytotoxicity of fragmented α-synuclein amyloid fibrils suggests intracellular basis for toxicity.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00562
Abstract: Aggregation and intracellular deposition of the protein α-synuclein is an underlying characteristic of Parkinson's disease. α-synuclein assemblies also undergo cell-cell spreading, facilitating propagation of their cellular pathology. Understanding how cellular interactions and uptake of extracellular… read more here.
Keywords: synuclein; amyloid fibrils; intracellular basis; cytotoxicity ... See more keywords
Structural Specificity of Polymorphic Forms of α-Synuclein Amyloid
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DOI: 10.3390/biomedicines11051324
Abstract: The structural transformation producing amyloids is a phenomenon that sheds new light on the protein folding problem. The analysis of the polymorphic structures of the α-synuclein amyloid available in the PDB database allows analysis of… read more here.
Keywords: polymorphic forms; synuclein amyloid; specificity polymorphic; micelle like ... See more keywords
The Aggregation Conditions Define Whether EGCG is an Inhibitor or Enhancer of α-Synuclein Amyloid Fibril Formation
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DOI: 10.3390/ijms21061995
Abstract: The amyloid fibril formation by α-synuclein is a hallmark of various neurodegenerative disorders, most notably Parkinson’s disease. Epigallocatechin gallate (EGCG) has been reported to be an efficient inhibitor of amyloid formation by numerous proteins, among… read more here.
Keywords: fibril formation; synuclein amyloid; amyloid fibril; formation ... See more keywords
Rapid restructurization of conformationally-distinct alpha-synuclein amyloid fibrils at an elevated temperature
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DOI: 10.7717/peerj.14137
Abstract: Protein aggregation in the form of amyloid fibrils is linked with the onset and progression of more than 30 amyloidoses, including multiple neurodegenerative disorders, such as Alzheimer’s or Parkinson’s disease. Despite countless studies and years… read more here.
Keywords: alpha; alpha synuclein; synuclein amyloid; amyloid fibrils ... See more keywords