Mapping Conformational and Kinetic Landscapes of 14-3-3σ/α-Synuclein Assembly via Variational Autoencoders and Markov State Models.
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DOI: 10.1021/acs.jcim.5c02323
Abstract: The interaction between the molecular chaperone 14-3-3σ and the intrinsically disordered protein α-synuclein is implicated in the pathogenesis of Parkinson's disease, yet its dynamic mechanism remains poorly understood at an atomistic level. The inherent flexibility… read more here.
Keywords: synuclein assembly; mapping conformational; variational autoencoders; state models ... See more keywords