Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity
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DOI: 10.1016/j.redox.2019.101135
Abstract: The aggregation of α-synuclein (α-syn) into amyloid fibrils is a major pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. The mechanisms underlying the structural transition of soluble and innocuous α-syn to aggregated neurotoxic forms… read more here.
Keywords: conformational ensemble; biasing native; synuclein conformational; syn ... See more keywords