Structural optimization of inhibitors of α-synuclein fibril growth: affinity to the fibril end as a crucial factor.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.11.019
Abstract: BACKGROUND Misfolding of the neuronal protein α-synuclein into amyloid fibrils is a pathological hallmark of Parkinson's disease, a neurodegenerative disorder that has no cure. Inhibition of the fibril growth is considered a promising therapeutic approach.… read more here.
Keywords: synuclein fibril; affinity; fibril growth; affinity fibril ... See more keywords
α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-018-0537-x
Abstract: Neuronal inclusions composed of α-synuclein (α-syn) characterize Parkinson’s Disease (PD) and Dementia with Lewy bodies (DLB). Cognitive dysfunction defines DLB, and up to 80% of PD patients develop dementia. α-Syn inclusions are abundant in the… read more here.
Keywords: hippocampal neurons; synuclein fibril; fibril induced; syn ... See more keywords