Modulation of α-Synuclein Fibrillation by Ultrasmall and Biocompatible Gold Nanoclusters.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00550
Abstract: Parkinson's disease (PD) is the second most common neurodegenerative disorder, the pathogenesis of which is closely linked to the misfolding and aggregation of the neuronal protein α-Synuclein (A-Syn). Numerous molecules that inhibit/modulate the pathogenic aggregation… read more here.
Keywords: fibrillation; bbb permeability; gold nanoclusters; synuclein fibrillation ... See more keywords
Inhibitory effect of mitoquinone against the α-synuclein fibrillation and relevant neurotoxicity: possible role in inhibition of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Biological Chemistry"
DOI: 10.1515/hsz-2021-0312
Abstract: Abstract Extensive studies have reported that interaction of α-synuclein amyloid species with neurons is a crucial mechanistic characteristic of Parkinson’s disease (PD) and small molecules can downregulate the neurotoxic effects induced by protein aggregation. However,… read more here.
Keywords: relevant neurotoxicity; synuclein fibrillation; synuclein; parkinson disease ... See more keywords