Oral and intravenous transmission of α-synuclein fibrils to mice
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica"
DOI: 10.1007/s00401-019-02037-5
Abstract: Parkinson’s disease and related disorders are neuropathologically characterized by cellular deposits of misfolded and aggregated α-synuclein in the CNS. Disease-associated α-synuclein adopts a conformation that causes it to form oligomers and fibrils, which have reduced… read more here.
Keywords: synuclein; challenge; oral intravenous; synuclein fibrils ... See more keywords
Cathepsin K is a potent disaggregase of α-synuclein fibrils.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.155
Abstract: The intracellular accumulation of α-synuclein (α-syn) amyloid fibrils is a hallmark of Parkinson's disease. Because lysosomes are responsible for degrading aggregated species, enhancing lysosomal function could alleviate the overburden of α-syn. Previously, we showed that… read more here.
Keywords: cathepsin potent; synuclein; syn; potent disaggregase ... See more keywords
Fluorescent Probe for Selective Imaging of α-Synuclein Fibrils in Living Cells.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00090
Abstract: Plaques of amyloid fibrils composed of neuronal protein α-synuclein are one of the hallmarks of Parkinson's disease, and their selective imaging is crucial to study the mechanism of its pathogenesis. However, the existing fluorescent probes… read more here.
Keywords: selective imaging; synuclein; probe; living cells ... See more keywords
Partially oxidized DJ-1 inhibits α-synuclein nucleation and remodels mature α-synuclein fibrils in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Communications Biology"
DOI: 10.1038/s42003-019-0644-7
Abstract: DJ-1 is a deglycase enzyme which exhibits a redox-sensitive chaperone-like activity. The partially oxidized state of DJ-1 is active in inhibiting the aggregation of α-synuclein, a key protein associated with Parkinson’s disease. The underlying molecular mechanism… read more here.
Keywords: aggregation; synuclein; remodels mature; partially oxidized ... See more keywords
Chemical disaggregation of alpha-synuclein fibrils as a therapy for synucleinopathies.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2300965120
Abstract: Protein aggregate formed by alpha-synuclein is the hallmark of a series of neurodegenerative disorders known as synucleinopathies (also known as Lewy body diseases), including Parkinson’s disease (PD), dementia with Lewy bodies, and multiple system atrophy… read more here.
Keywords: synuclein; alpha synuclein; synuclein fibrils; disaggregation alpha ... See more keywords
α-Synuclein Fibrils as Penrose Machines: A Chameleon in the Gear
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12040494
Abstract: In 1957, Lionel Penrose built the first man-made self-replicating mechanical device and illustrated its function in a series of machine prototypes, prefiguring our current view of the genesis and the proliferation of amyloid fibrils. He… read more here.
Keywords: machines chameleon; chameleon gear; penrose machines; synuclein fibrils ... See more keywords