Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution.
Sign Up to like & getrecommendations! Published in 2020 at "Nano letters"
DOI: 10.1021/acs.nanolett.0c03260
Abstract: Oligomers comprised of misfolded proteins are implicated as neurotoxins in the pathogenesis of protein misfolding conditions such as Parkinson's and Alzheimer's diseases. Structural, biophysical, and biochemical characterization of these nanoscale protein assemblies is key to… read more here.
Keywords: synuclein; structural kinetic; analysis; synuclein oligomers ... See more keywords
Structural characteristics and membrane interactions of tandem α-synuclein oligomers
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DOI: 10.1038/s41598-018-25133-0
Abstract: Pre-fibrillar oligomers of α-synuclein are thought to be pathogenic molecules leading to neurotoxicity associated with Parkinson’s disease and other neurodegenerative disorders. However, small oligomers are difficult to isolate for study. To gain better insight into… read more here.
Keywords: characteristics membrane; structural characteristics; synuclein oligomers; tandem synuclein ... See more keywords
An antibody scanning method for the detection of α-synuclein oligomers in the serum of Parkinson's disease patients
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DOI: 10.1039/d2sc00066k
Abstract: Misfolded α-synuclein oligomers are closely implicated in the pathology of Parkinson's disease and related synucleinopathies. The elusive nature of these aberrant assemblies makes it challenging to develop quantitative methods to detect them and modify their… read more here.
Keywords: disease patients; parkinson disease; synuclein; synuclein oligomers ... See more keywords
Comparing GBA1‐Parkinson's disease and idiopathic Parkinson's disease: α‐Synuclein oligomers and synaptic density as biomarkers in the skin biopsy
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DOI: 10.1111/bpa.13284
Abstract: The main genetic risk factors for Parkinson's disease (PD) are presently represented by variants in GBA1 gene encoding for the β‐glucocerebrosidase (GCase). Searching for a peripheral biomarker that can be used for selecting and monitoring… read more here.
Keywords: synuclein oligomers; synaptic density; parkinson disease;
The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27041293
Abstract: A wide variety of oligomeric structures are formed during the aggregation of proteins associated with neurodegenerative diseases. Such soluble oligomers are believed to be key toxic species in the related disorders; therefore, identification of the… read more here.
Keywords: mutation alpha; g51d mutation; pathological g51d; toxicity ... See more keywords