Changes in CD200 and intercellular adhesion molecule-1 (ICAM-1) levels in brains of Lewy body disorder cases are associated with amounts of Alzheimer's pathology not α-synuclein pathology
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.03.007
Abstract: Enhanced inflammation has been associated with Alzheimer's disease (AD) and diseases with Lewy body (LB) pathology, such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB). One issue is whether amyloid and tangle pathology,… read more here.
Keywords: synuclein pathology; pathology; icam; adhesion molecule ... See more keywords
APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid
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DOI: 10.1126/scitranslmed.aay1809
Abstract: APOE4 exacerbates α-synuclein pathology in a synucleinopathy mouse model, and APOE4 genotype associates with increased α-synuclein pathology in humans. APOE4 beyond amyloid Although several genetic risk factors for neurodegenerative disorders have been identified, often the… read more here.
Keywords: synuclein pathology; apoe4 exacerbates; mouse; pathology ... See more keywords
Analysis of α-Synuclein Pathology in PINK1 Knockout Rat Brains
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DOI: 10.3389/fnins.2018.01034
Abstract: Mutations in PTEN induced kinase 1 (PINK1) cause autosomal recessive Parkinson’s disease (PD). The main pathological hallmarks of PD are loss of dopaminergic neurons in the substantia nigra pars compacta and the formation of protein… read more here.
Keywords: pink1 knockout; synuclein pathology; synuclein; pathology ... See more keywords
Early Forms of α-Synuclein Pathology Are Associated with Neuronal Complex I Deficiency in the Substantia Nigra of Individuals with Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12060747
Abstract: Idiopathic Parkinson’s disease (iPD) is characterized by degeneration of the dopaminergic substantia nigra pars compacta (SNc), typically in the presence of Lewy pathology (LP) and mitochondrial respiratory complex I (CI) deficiency. LP is driven by… read more here.
Keywords: complex deficiency; substantia nigra; parkinson disease; pathology ... See more keywords