α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model
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DOI: 10.1002/advs.202409040
Abstract: Understanding the progression of α‐synuclein pathology in neurodegenerative diseases such as Parkinson's disease (PD) is a longstanding challenge. Here, a novel midbrain–hindbrain‐assembloid model that recapitulates the spread of α‐synuclein pathology observed in PD patients, akin… read more here.
Keywords: pathology; model; synuclein pathology; midbrain hindbrain ... See more keywords
Nanotherapeutic Approaches of Interleukin‐3 to Clear the α‐Synuclein Pathology in Mouse Models of Parkinson's Disease (Adv. Sci. 42/2024)
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DOI: 10.1002/advs.202470257
Abstract: Parkinson's Disease IL‐3 is a promising therapeutic target in neurodegenerative diseases. Breaking through its limitation of crossing blood‐brain barrier, the article number 2405364 by Ruijing Liang, Yunlong Zhang, and co‐workers reveals a novel nanogel delivery… read more here.
Keywords: nanotherapeutic approaches; interleukin clear; pathology; approaches interleukin ... See more keywords
Changes in CD200 and intercellular adhesion molecule-1 (ICAM-1) levels in brains of Lewy body disorder cases are associated with amounts of Alzheimer's pathology not α-synuclein pathology
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.03.007
Abstract: Enhanced inflammation has been associated with Alzheimer's disease (AD) and diseases with Lewy body (LB) pathology, such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB). One issue is whether amyloid and tangle pathology,… read more here.
Keywords: synuclein pathology; pathology; icam; adhesion molecule ... See more keywords
APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid
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DOI: 10.1126/scitranslmed.aay1809
Abstract: APOE4 exacerbates α-synuclein pathology in a synucleinopathy mouse model, and APOE4 genotype associates with increased α-synuclein pathology in humans. APOE4 beyond amyloid Although several genetic risk factors for neurodegenerative disorders have been identified, often the… read more here.
Keywords: synuclein pathology; apoe4 exacerbates; mouse; pathology ... See more keywords
Pathological α-synuclein elicits granulovacuolar degeneration independent of tau
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DOI: 10.1186/s40035-025-00494-5
Abstract: Background Pathologic heterogeneity is a hallmark of Lewy body dementia (LBD), yet the impact of Lewy pathology on co-pathologies is poorly understood. Lewy pathology, containing α-synuclein, is often associated with regional tau pathology burden in… read more here.
Keywords: pathology; granulovacuolar degeneration; tau; synuclein pathology ... See more keywords
Tet2 loss and enhanced ciliogenesis suppress α-synuclein pathology
Sign Up to like & getrecommendations! Published in 2025 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-025-01988-z
Abstract: There are no approved treatments that slow Parkinson’s disease (PD) progression and therefore it is important to identify novel pathogenic mechanisms that can be targeted. Loss of the epigenetic marker, Tet2 appears to have some… read more here.
Keywords: tet2 loss; pathology; ciliogenesis; synuclein pathology ... See more keywords
Analysis of α-Synuclein Pathology in PINK1 Knockout Rat Brains
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DOI: 10.3389/fnins.2018.01034
Abstract: Mutations in PTEN induced kinase 1 (PINK1) cause autosomal recessive Parkinson’s disease (PD). The main pathological hallmarks of PD are loss of dopaminergic neurons in the substantia nigra pars compacta and the formation of protein… read more here.
Keywords: pink1 knockout; synuclein pathology; synuclein; pathology ... See more keywords
Early Forms of α-Synuclein Pathology Are Associated with Neuronal Complex I Deficiency in the Substantia Nigra of Individuals with Parkinson’s Disease
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DOI: 10.3390/biom12060747
Abstract: Idiopathic Parkinson’s disease (iPD) is characterized by degeneration of the dopaminergic substantia nigra pars compacta (SNc), typically in the presence of Lewy pathology (LP) and mitochondrial respiratory complex I (CI) deficiency. LP is driven by… read more here.
Keywords: complex deficiency; substantia nigra; parkinson disease; pathology ... See more keywords
α-Synuclein Pathology in Synucleinopathies: Mechanisms, Biomarkers, and Therapeutic Challenges
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26115405
Abstract: Parkinson’s disease and related synucleinopathies, including dementia with Lewy bodies and multiple system atrophy, are characterised by the pathological aggregation of the α-synuclein (aSyn) protein in neuronal and glial cells, leading to cellular dysfunction and… read more here.
Keywords: mechanisms biomarkers; pathology; biomarkers therapeutic; pathology synucleinopathies ... See more keywords