α‐Synuclein Seed Amplification in CSF and Brain from Patients with Different Brain Distributions of Pathological α‐Synuclein in the Context of Co‐Pathology and Non‐LBD Diagnoses
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DOI: 10.1002/ana.26453
Abstract: The purpose of this study was to determine the sensitivity and specificity of α‐synuclein seed amplification assay (αSyn‐SAA) in antemortem and postmortem cerebrospinal fluid (CSF) of autopsy‐confirmed patients with different distributions of pathological αSyn, co‐pathologies,… read more here.
Keywords: seed amplification; brain; patients different; pathology ... See more keywords
High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-021-01282-8
Abstract: Alpha-synuclein seed amplification assays (αSyn-SAAs) are promising diagnostic tools for Parkinson’s disease (PD) and related synucleinopathies. They enable detection of seeding-competent alpha-synuclein aggregates in living patients and have shown high diagnostic accuracy in several PD… read more here.
Keywords: seed; syn saa; synuclein seed; alpha synuclein ... See more keywords