A luminescence-based assay for monitoring changes in alpha-synuclein aggregation in living cells†
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DOI: 10.1039/d0ra02720k
Abstract: Parkinson’s disease is characterized by the accumulation of protein aggregates in the brain, termed Lewy bodies. Lewy bodies are predominantly composed of α-synuclein and mutations that increase the aggregation potential of α-synuclein have been associated… read more here.
Keywords: synuclein aggregation; aggregation; synuclein solubility; living cells ... See more keywords