Alpha and Beta Synucleins: From Pathophysiology to Clinical Application as Biomarkers
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.28941
Abstract: The synuclein family includes three neuronal proteins, named α‐synuclein, β‐synuclein, and γ‐synuclein, that have peculiar structural features. α‐synuclein is largely known for being a key protein in the pathophysiology of Parkinson's disease (PD) and other… read more here.
Keywords: application; alpha beta; beta synucleins; synuclein ... See more keywords
Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110675
Abstract: α-synuclein, β-synuclein, and γ-synuclein are abundantly expressed proteins in the vertebrate nervous system. α-synuclein functions in neurotransmitter release by binding to and clustering synaptic vesicles and chaperoning SNARE-complex assembly. Pathologically, aggregates originating from soluble pools… read more here.
Keywords: synaptic vesicle; binding synuclein; vesicle binding; synuclein ... See more keywords