LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Society transactions"
DOI: 10.1042/bst20180466
Abstract: The identification of genetic forms of Parkinson's disease (PD) has tremendously expanded our understanding of the players and mechanisms involved. Mutations in the genes encoding for alpha-synuclein (aSyn), LRRK2, and tau have been associated with… read more here.
Keywords: lrrk2 alpha; synuclein tau; partners crime; tau partners ... See more keywords
Ambroxol reverses tau and α-synuclein accumulation in a cholinergic N370S GBA1 mutation model.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac038
Abstract: Cognitive impairment is a common non-motor complication of Parkinson disease (PD). Glucocerebrosidase gene (GBA1) variants are found in 10-15% of PD cases and are numerically the most important risk factor for PD and dementia with… read more here.
Keywords: synuclein tau; n370s gba1; cholinergic neurons; gba1 mutation ... See more keywords
Single-domain antibody–based noninvasive in vivo imaging of α-synuclein or tau pathology
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf3775
Abstract: Intracellular deposition of α-synuclein and tau are hallmarks of synucleinopathies and tauopathies, respectively. Recently, several dye-based imaging probes with selectivity for tau aggregates have been developed, but suitable imaging biomarkers for synucleinopathies are still unavailable.… read more here.
Keywords: imaging synuclein; synuclein tau; pathology; vivo imaging ... See more keywords
Absence of Uptake and Prion-Like Spreading of Alpha-Synuclein and Tau After Intravitreal Injection of Preformed Fibrils
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2020.614587
Abstract: Although very different in etiology and symptoms, numerous neurodegenerative diseases can be classified as proteinopathies. More so, evidence indicates that the key misfolded proteins at the basis of different neuropathies might share common mechanisms of… read more here.
Keywords: intravitreal injection; prion like; like spreading; prion ... See more keywords
Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00107
Abstract: Alzheimer's disease (AD) and Parkinson's disease (PD) are age-associated neurodegenerative disorders characterized by the misfolding and aggregation of alpha-synuclein (aSyn) and tau, respectively. The coexistence of aSyn and tau aggregates suggests a strong overlap between… read more here.
Keywords: tau systematic; systematic comparison; spreading synuclein; asyn tau ... See more keywords