The golden (Syrian) hamster as a model for the study of reproductive biology: Past, present, and future
Sign Up to like & getrecommendations! Published in 2019 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12241
Abstract: The golden (Syrian) hamster (Mesocricetus auratus) is a small rodent that belongs to the Cricetidae family. It has several unique features that are advantageous for the study of reproductive and developmental biology, including a consistent… read more here.
Keywords: hamster model; golden syrian; study reproductive; syrian hamster ... See more keywords
Syrian Hamster as an Advanced Experimental Model for Visceral Leishmaniasis.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9210-2_17
Abstract: Animal models are needed along the development and evaluation of potential chemotherapeutic agents against leishmaniasis. Infections of Syrian hamsters with Leishmania species causing visceral leishmaniasis (VL) closely mimic the disease in the natural hosts, including… read more here.
Keywords: model; syrian hamster; hamster advanced; visceral leishmaniasis ... See more keywords
Modifications of the axon initial segment during the hibernation of the Syrian hamster
Sign Up to like & getrecommendations! Published in 2018 at "Brain Structure and Function"
DOI: 10.1007/s00429-018-1753-7
Abstract: Mammalian hibernation is a natural process in which the brain undergoes profound adaptive changes that appear to protect the brain from extreme hypoxia and hypothermia. In addition to a virtual cessation of neural and metabolic… read more here.
Keywords: initial segment; axon initial; hibernation; hibernation syrian ... See more keywords
Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological, and pathological disease in a Syrian hamster model of COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2047144
Abstract: ABSTRACT There remains an unmet need for globally deployable, low-cost therapeutics for the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Previously, we reported on the isolation and in vitro characterization of a potent… read more here.
Keywords: rbd; cov rbd; syrian hamster; covnb 112 ... See more keywords
Distinct spatial arrangements of ACE2 and TMPRSS2 expression in Syrian hamster lung lobes dictates SARS-CoV-2 infection patterns
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010340
Abstract: SARS-CoV-2 attaches to angiotensin-converting enzyme 2 (ACE2) to gain entry into cells after which the spike protein is cleaved by the transmembrane serine protease 2 (TMPRSS2) to facilitate viral-host membrane fusion. ACE2 and TMPRSS2 expression… read more here.
Keywords: tmprss2 expression; infection; expression; syrian hamster ... See more keywords
Meibomian adenoma in a Syrian hamster (Mesocricetus auratus): a case report.
Sign Up to like & getrecommendations! Published in 2018 at "Veterinarni Medicina"
DOI: 10.17221/7184-vetmed
Abstract: A two-year old male Syrian hamster ( Mesocricetus auratus) was brought to the Surgery Clinic at the Istanbul University, Veterinary Faculty, Research and Practice Hospital, with a non-healing wound on the right upper eyelid. An… read more here.
Keywords: mesocricetus auratus; syrian hamster; hamster mesocricetus; meibomian adenoma ... See more keywords
Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1060540
Abstract: Introduction Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer, but preclinical testing of hypotheses such as combination therapies has been complicated, in part due to species incompatibility issues. For example, one of few… read more here.
Keywords: growth control; hamster; tumour growth; syrian hamster ... See more keywords
Syrian hamster as an ideal animal model for evaluation of cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1126969
Abstract: Cancer immunotherapy (CIT) has emerged as an exciting new pillar of cancer treatment. Although benefits have been achieved in individual patients, the overall response rate is still not satisfactory. To address this, an ideal preclinical… read more here.
Keywords: animal model; cancer; cancer immunotherapy; syrian hamster ... See more keywords
Molecular Basis of White Adipose Tissue Remodeling That Precedes and Coincides With Hibernation in the Syrian Hamster, a Food-Storing Hibernator
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.01973
Abstract: Mammalian hibernators store fat extensively in white adipose tissues (WATs) during pre-hibernation period (Pre-HIB) to prepare for hibernation. However, the molecular mechanisms underlying the pre-hibernation remodeling of WAT have not been fully elucidated. Syrian hamsters,… read more here.
Keywords: storing hibernator; hibernation; food storing; white adipose ... See more keywords
Cardiopulmonary Injury in the Syrian Hamster Model of COVID-19
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DOI: 10.3390/v14071403
Abstract: The Syrian hamster has proved useful in the evaluation of therapeutics and vaccines for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). To advance the model for preclinical studies, we conducted serial sacrifice of lungs, large pulmonary vessels,… read more here.
Keywords: hamster; cardiopulmonary injury; infection; model ... See more keywords
SARS-CoV-2 Disease Severity in the Golden Syrian Hamster Model of Infection Is Related to the Volume of Intranasal Inoculum
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15030748
Abstract: The golden Syrian hamster (Mesocricetus auratus) is now commonly used in preclinical research for the study of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the assessment of vaccines, drugs and therapeutics. Here, we… read more here.
Keywords: volume; golden syrian; severity; syrian hamster ... See more keywords