Seeded assembly in vitro does not replicate the structures of α‐synuclein filaments from multiple system atrophy
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DOI: 10.1002/2211-5463.13110
Abstract: The propagation of conformational strains by templated seeding is central to the prion concept. Seeded assembly of α‐synuclein into filaments is believed to underlie the prion‐like spreading of protein inclusions in a number of human… read more here.
Keywords: synuclein filaments; seeded assembly; structures synuclein; system atrophy ... See more keywords
Clinicopathological correlates of pyramidal signs in multiple system atrophy
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DOI: 10.1002/acn3.51576
Abstract: Pyramidal signs are common but often under‐recognized in multiple system atrophy (MSA). The clinicopathological correlates of pyramidal signs in MSA are not well characterized. The present study aims to understand the role of pyramidal signs… read more here.
Keywords: correlates pyramidal; clinicopathological correlates; multiple system; system atrophy ... See more keywords
Biallelic Intronic AAGGG Expansion of RFC1 is Related to Multiple System Atrophy
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DOI: 10.1002/ana.25902
Abstract: A recessive biallelic repeat expansion, (AAGGG)exp, in the RFC1 gene has been reported to be a frequent cause of late‐onset ataxia. For cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS), the recessive biallelic (AAGGG)exp genotype… read more here.
Keywords: aaggg; expansion; system atrophy; related multiple ... See more keywords
The differential diagnostic value of a battery of oculomotor evaluation in Parkinson's Disease and Multiple System Atrophy
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DOI: 10.1002/brb3.2184
Abstract: Clinical diagnosis of Parkinsonism is still challenging, and the diagnostic biomarkers of Multiple System Atrophy (MSA) are scarce. This study aimed to investigate the diagnostic value of the combined eye movement tests in patients with… read more here.
Keywords: diagnostic value; multiple system; system atrophy; parkinson disease ... See more keywords
Clinical outcomes and cognitive impairments between progressive supranuclear palsy and multiple system atrophy
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DOI: 10.1002/brb3.2827
Abstract: Both progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) belong to atypical parkinsonian syndromes. It is important to differentiate these diseases accurately. We compared clinical outcomes and cognitive impairments between PSP and MSA. read more here.
Keywords: clinical outcomes; progressive supranuclear; multiple system; outcomes cognitive ... See more keywords
Functional connectome automatically differentiates multiple system atrophy (parkinsonian type) from idiopathic Parkinson's disease at early stages
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DOI: 10.1002/hbm.26201
Abstract: Differentiating the parkinsonian variant of multiple system atrophy (MSA‐P) from idiopathic Parkinson's disease (IPD) is challenging, especially in the early stages. This study aimed to investigate differences and similarities in the brain functional connectomes of… read more here.
Keywords: functional connectome; msa; multiple system; system atrophy ... See more keywords
Skill Training Resulted in Improved Swallowing in a Person with Multiple System Atrophy: An Endoscopy Study
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DOI: 10.1002/mdc3.12628
Abstract: Dysphagia is a frequent symptom of multiple system atrophy (MSA). Current dysphagia management is compensatory, involving thickening liquids, postural maneuvers, or enteral feeding. There are no studies of dysphagia rehabilitation in MSA. We found that… read more here.
Keywords: skill training; atrophy; system atrophy; multiple system ... See more keywords
Can Autonomic Testing and Imaging Contribute to the Early Diagnosis of Multiple System Atrophy? A Systematic Review and Recommendations by the Movement Disorder Society Multiple System Atrophy Study Group
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DOI: 10.1002/mdc3.13052
Abstract: In the current consensus diagnostic criteria, the diagnosis of probable multiple system atrophy (MSA) is based solely on clinical findings, whereas neuroimaging findings are listed as aid for the diagnosis of possible MSA. There are… read more here.
Keywords: multiple system; system atrophy; diagnosis;
Patient‐Reported Symptoms in the Global Multiple System Atrophy Registry
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DOI: 10.1002/mdc3.13544
Abstract: The Global Multiple System Atrophy Registry (GLOMSAR) was established in 2013. It is an online patient‐reported contact registry open and free that relies on self‐reported diagnosis by the patient or caregiver. read more here.
Keywords: atrophy registry; multiple system; system atrophy; registry ... See more keywords
Epidural Spinal Cord Stimulation to Treat Neurogenic Orthostatic Hypotension in Multiple System Atrophy: A New Hope?
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DOI: 10.1002/mdc3.13583
Abstract: Multiple system atrophy (MSA) is a neurodegenerative movement disorder clinically characterized by a combination of different degrees of parkinsonism, cerebellar ataxia, and autonomic dysfunction. MSA is rapidly progressive, leading patients to be wheelchair bound within… read more here.
Keywords: orthostatic hypotension; neurogenic orthostatic; hypotension; multiple system ... See more keywords
Creutzfeldt–Jakob Disease Misdiagnosed as Multiple System Atrophy
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DOI: 10.1002/mdc3.13654
Abstract: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by various combinations of autonomic failure, parkinsonism, and cerebellar syndromes. Although consensus criteria have been widely used to diagnose MSA, accurate clinical diagnosis remains challenging.… read more here.
Keywords: creutzfeldt jakob; jakob disease; multiple system; system atrophy ... See more keywords