System biology-based investigation of Silymarin to trace hepatoprotective effect
Sign Up to like & getrecommendations! Published in 2022 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2022.105223
Abstract: Silymarin is used as a hepatoprotective agent since ancient times which could be via its potent anti-oxidant effect. However, the mode of silymarin for the hepatoprotective effect has not been established with the targets involved… read more here.
Keywords: silymarin; hepatoprotective effect; system biology; biology ... See more keywords
Combination of system biology to probe the anti-viral activity of andrographolide and its derivative against COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d0ra10529e
Abstract: The present study aimed to investigate the binding affinity of andrographolide and its derivative i.e., 14-deoxy-11,12-didehydroandrographolide with targets related to COVID-19 and their probable role in regulating multiple pathways in COVID-19 infection. SMILES of both… read more here.
Keywords: covid; system biology; andrographolide derivative; combination system ... See more keywords
System biology and bioinformatics pipeline to identify comorbidities risk association: Neurodegenerative disorder case study
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0250660
Abstract: Alzheimer’s disease (AD) is the commonest progressive neurodegenerative condition in humans, and is currently incurable. A wide spectrum of comorbidities, including other neurodegenerative diseases, are frequently associated with AD. How AD interacts with those comorbidities… read more here.
Keywords: system biology; pipeline; gene expression; biology ... See more keywords
Human Disease System Biology.
Sign Up to like & getrecommendations! Published in 2018 at "Current gene therapy"
DOI: 10.2174/1566523218666181010101114
Abstract: In recent years, genome-wide association studies (GWAS) and next-generation sequencing technologies have been widely used to detect the common genetic variants of diseases. Despite these successes, the majority of genetic architecture of human complex diseases… read more here.
Keywords: disease system; system biology; disease; biology ... See more keywords
The Many-Faced Program of Epithelial–Mesenchymal Transition: A System Biology-Based View
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2017.00274
Abstract: System biology uses a range of experimental and statistical methods to dissect complex processes that results from alterations in biological models. Given the complexity of the epithelial–mesenchymal transition (EMT) program, system biology represents a promising… read more here.
Keywords: system biology; mesenchymal transition; epithelial mesenchymal; biology ... See more keywords