Systematic drug sensitivity testing reveals synergistic growth inhibition by dasatinib or mTOR inhibitors with paclitaxel in ovarian granulosa cell tumor cells.
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DOI: 10.1016/j.ygyno.2016.12.016
Abstract: OBJECTIVE Resistance to standard chemotherapy poses a major clinical problem in the treatment of ovarian cancer patients. Adult-type granulosa cell tumor (AGCT) is a unique ovarian cancer subtype for which efficient treatment options are lacking… read more here.
Keywords: dasatinib mtor; granulosa; drug; sensitivity ... See more keywords
Systematic drug repositioning through mining adverse event data in ClinicalTrials.gov
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DOI: 10.7717/peerj.3154
Abstract: Drug repositioning (i.e., drug repurposing) is the process of discovering new uses for marketed drugs. Historically, such discoveries were serendipitous. However, the rapid growth in electronic clinical data and text mining tools makes it feasible… read more here.
Keywords: mining; drug repositioning; clinicaltrials gov; drug ... See more keywords