Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddx432
Abstract: Huntington's disease (HD) is a dominantly inherited neurodegenerative disease caused by alterations in the huntingtin gene (htt). Transcriptional dysregulation is an early event in HD progression. Protein acetylation and methylation particularly on histones regulates chromatin… read more here.
Keywords: systematic genetic; huntington disease; disease; pathology ... See more keywords