Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddx432
Abstract: Huntington's disease (HD) is a dominantly inherited neurodegenerative disease caused by alterations in the huntingtin gene (htt). Transcriptional dysregulation is an early event in HD progression. Protein acetylation and methylation particularly on histones regulates chromatin… read more here.
Keywords: systematic genetic; huntington disease; disease; pathology ... See more keywords
Systematic Genetic Assessment in Young Patients With Cryptogenic Stroke: The ES-EASY project.
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DOI: 10.1161/strokeaha.125.051020
Abstract: BACKGROUND Up to 15% of strokes occur in young adults, with more cryptogenic cases, raising the possibility of rare causes, such as genetic diseases. Although available in everyday practice, genetic analyses are usually reserved for… read more here.
Keywords: genetic analyses; cohort; history; systematic genetic ... See more keywords