Abstract IA08: Systematic interrogation of cancer dependencies
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1538-8514.synthleth-ia08
Abstract: Although we now have a draft view of the genetic alterations that occur in human cancer, the number of mutations found at low frequency and the molecular heterogeneity of most cancers makes identifying genes that… read more here.
Keywords: cancer dependencies; interrogation cancer; cancer; systematic interrogation ... See more keywords
Abstract IA25: Systematic interrogation of KRAS function
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-ia25
Abstract: Oncogenic mutations of KRAS occur frequently in pancreas, lung and colon cancers. Recent efforts to target particular KRAS alleles or RAS effector pathways has led to clinical responses but resistance to therapy limits the effectiveness… read more here.
Keywords: systematic interrogation; abstract ia25; kras function; driven cancers ... See more keywords
Systematic interrogation of mutation groupings reveals divergent downstream expression programs within key cancer genes
Sign Up to like & getrecommendations! Published in 2021 at "BMC Bioinformatics"
DOI: 10.1186/s12859-021-04147-y
Abstract: Background Genes implicated in tumorigenesis often exhibit diverse sets of genomic variants in the tumor cohorts within which they are frequently mutated. For many genes, neither the transcriptomic effects of these variants nor their relationship… read more here.
Keywords: downstream expression; expression; cancer; systematic interrogation ... See more keywords