Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Brain Research"
DOI: 10.1007/s00221-017-5023-3
Abstract: Systemic administration of a Connexin43 mimetic peptide, Peptide5, has been shown to reduce secondary tissue damage and improve functional recovery after spinal cord injury (SCI). This study investigated safety measures and potential off-target effects of… read more here.
Keywords: peptide5 systemic; spinal cord; systemic administration;
Gene expression changes in the retina after systemic administration of aldosterone
Sign Up to like & getrecommendations! Published in 2018 at "Japanese Journal of Ophthalmology"
DOI: 10.1007/s10384-018-0595-4
Abstract: PurposeRetinal ganglion cell (RGC) loss associated with thinning of the retinal nerve fiber layer without elevated intraocular pressure (IOP) occurs after the systemic administration of aldosterone. Since it is important to determine the mechanism of… read more here.
Keywords: administration aldosterone; gene expression; aldosterone; systemic administration ... See more keywords
Clinical analysis of systemic administration combined with microwave ablation in the treatment of lung cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Asian journal of surgery"
DOI: 10.1016/j.asjsur.2021.08.013
Abstract: OBJECTIVE To explore the therapeutic effect of systemic administration combined with microwave ablation (MWA) under computed tomography (CT) and fiberoptic bronchoscope for treating lung cancer. METHODS Sixty-six patients with advanced lung cancer admitted to our… read more here.
Keywords: treatment; lung cancer; group; systemic administration ... See more keywords
Bilayered buccal films as child-appropriate dosage form for systemic administration of propranolol.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.08.070
Abstract: Buccal mucosa has emerged as an attractive site for systemic administration of drug in paediatric patients. This route is simple and non-invasive, even if the saliva wash-out effect and the relative permeability of the mucosa… read more here.
Keywords: systemic administration; layer; buccal films; drug ... See more keywords
Brain uptake of multivalent and multi-specific DVD-Ig proteins after systemic administration
Sign Up to like & getrecommendations! Published in 2018 at "mAbs"
DOI: 10.1080/19420862.2018.1465159
Abstract: ABSTRACT Therapeutic monoclonal antibodies and endogenous IgG antibodies show limited uptake into the central nervous system (CNS) due to the blood-brain barrier (BBB), which regulates and controls the selective and specific transport of both exogenous… read more here.
Keywords: systemic administration; brain; brain uptake; dvd proteins ... See more keywords
Design and Evaluation of Systemic Administration of Nano Silica MCM48:Eu3+ in Mouse Brain
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the Brazilian Chemical Society"
DOI: 10.21577/0103-5053.20230056
Abstract: In the present study, we tested the proof of concept that mobil mesoporous silica nanoparticle composition of matter (MCM) No. 48 doped with trivalent europium (nanoMCM48:Eu3+) administered systemically intravenously can act as a suitable vehicle… read more here.
Keywords: systemic administration; brain; eu3; mcm48 eu3 ... See more keywords
Effect of Systemic Administration of Amitriptyline on Oral Microbes in Rats
Sign Up to like & getrecommendations! Published in 2022 at "In Vivo"
DOI: 10.21873/invivo.12939
Abstract: Abstract Background/Aim: Amitriptyline is a major tricyclic antidepressant that is also used to relieve chronic orofacial pain. Recently, alterations in gut flora due to various antidepressants have been demonstrated. However, it remains unknown how antidepressants… read more here.
Keywords: administration; systemic administration; antimicrobial peptides; administration amitriptyline ... See more keywords
Systemic Administration of Lipopolysaccharide from Porphyromonas gingivalis Decreases Neprilysin Expression in the Mouse Hippocampus
Sign Up to like & getrecommendations! Published in 2023 at "In Vivo"
DOI: 10.21873/invivo.13065
Abstract: Abstract Background/Aim: Alzheimer’s disease is the most common type of neurodegenerative disorder in elderly individuals worldwide. Increasing evidence suggests that periodontal diseases are involved in the pathogenesis of Alzheimer’s disease, and an association between periodontitis… read more here.
Keywords: neprilysin expression; samp8 mice; systemic administration; expression ... See more keywords
Long-Term Functional and Cytoarchitectonic Effects of the Systemic Administration of the Histamine H1 Receptor Antagonist/Inverse Agonist Chlorpheniramine During Gestation in the Rat Offspring Primary Motor Cortex
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.740282
Abstract: The transient histaminergic system is among the first neurotransmitter systems to appear during brain development in the rat mesencephalon/rhombencephalon. Histamine increases FOXP2-positive deep-layer neuron differentiation of cortical neural stem cells through H1 receptor activation in… read more here.
Keywords: systemic administration; layer; histamine; chlorpheniramine ... See more keywords
Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.863762
Abstract: Cyclin-dependent kinase 5 (Cdk5) is a crucial regulator of neuronal signal transduction. Cdk5 activity is implicated in various neuropsychiatric and neurodegenerative conditions such as stress, anxiety, depression, addiction, Alzheimer’s disease, and Parkinson’s disease. While constitutive… read more here.
Keywords: cdk5 inhibitor; systemic administration; brain; administration brain ... See more keywords
HPMA Copolymer Mebendazole Conjugate Allows Systemic Administration and Possesses Antitumour Activity In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14061201
Abstract: Mebendazole and other benzimidazole antihelmintics, such as albendazole, fenbendazole, or flubendazole, have been shown to possess antitumour activity, primarily due to their microtubule-disrupting activity. However, the extremely poor water-solubility of mebendazole and other benzimidazoles, resulting… read more here.
Keywords: antitumour activity; mebendazole; systemic administration; activity ... See more keywords