A Photosensitizer Discretely Loaded Nanoaggregate with Robust Photodynamic Effect for Local Treatment Triggers Systemic Antitumor Responses.
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DOI: 10.1021/acsnano.1c10590
Abstract: Photodynamic therapy (PDT), is a rising star for suppression of in situ and metastatic tumors, yet it is impeded by low ROS production and off-target phototoxicity. Herein, an aggregation degree editing strategy, inspired by gene… read more here.
Keywords: antitumor responses; discretely loaded; icg; systemic antitumor ... See more keywords
Amelioration of systemic antitumor immune responses in cocktail therapy by immunomodulatory nanozymes
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DOI: 10.1126/sciadv.abn3883
Abstract: Nanozymes that mimic natural enzyme–like activities have gradually emerged in cancer therapy. To overcome the bottlenecks of single-mode nanozymes, including “off-target” toxicity and ineffectiveness toward metastatic cancers, we designed magnetic nanoparticle–based multifunctional visualized immunomodulatory nanozymes.… read more here.
Keywords: amelioration systemic; therapy; immunomodulatory nanozymes; systemic antitumor ... See more keywords
Combination of ultrasound-based mechanical disruption of tumor with immune checkpoint blockade modifies tumor microenvironment and augments systemic antitumor immunity
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003717
Abstract: Background Despite multimodal adjuvant management with radiotherapy, chemotherapy and hormonal therapies, most surgically resected primary breast cancers relapse or metastasize. A potential solution to late and distant recurrence is to augment systemic antitumor immunity, in… read more here.
Keywords: tumor; antitumor immunity; hifu; systemic antitumor ... See more keywords