Tetraspanin CD53 modulates lymphocyte trafficking but not systemic autoimmunity in Lyn-deficient mice.
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DOI: 10.1111/imcb.12501
Abstract: The leukocyte-restricted tetraspanin CD53 has been shown to promote lymphocyte homing to lymph nodes and myeloid cell recruitment to acutely inflamed peripheral organs, and accelerate the onset of immune-mediated disease. However, its contribution in the… read more here.
Keywords: systemic autoimmunity; lyn; mice; tetraspanin cd53 ... See more keywords
mTORC2 contributes to systemic autoimmunity
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DOI: 10.1111/imm.13594
Abstract: The development of many systemic autoimmune diseases, including systemic lupus erythematosus, is associated with overactivation of the type I interferon (IFN) pathway, lymphopenia and increased follicular helper T (Tfh)‐cell differentiation. However, the cellular and molecular… read more here.
Keywords: tfh differentiation; mtorc2; cell; systemic autoimmunity ... See more keywords
Keratinocytes: From passive targets to active mediators of systemic autoimmunity
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abo3961
Abstract: Keratinocyte-mediated interferon production in nonlesional skin drives activation of CD16+ dendritic cells and is associated with cutaneous inflammation in lupus (Billi et al.). Description Keratinocyte-mediated interferon production in nonlesional skin drives activation of CD16+ dendritic… read more here.
Keywords: passive targets; mediators systemic; systemic autoimmunity; targets active ... See more keywords